NFL Picks

NFL picks for every game of the 2025-26 season. Our NFL expert picks are informed by key betting trends, statistical analysis and years of NFL betting experience. +93.3 units profit, from 304 winning NFL picks across the 2025 regular season and playoffs is the proof.

NFL Picks against the spread and over/under for every game in the Divisional Round:

Bills vs Broncos

49ers vs Seahawks

Texans vs Patriots

Rams vs Bears

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Point Spread (1)Game Totals (1)

Experts

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4:30 PM ET

Sat Jan 17

CBS

Bills

Broncos

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Point Spread Pick

DEN Broncos +1.0(-110)

Reasoning

Many pontificators in the betting world thought the Jaguars would successfully move on to the Divisional Round, anchored by Liam Coen and their new-look defense. That never came to be. Instead, Buffalo secured their first road playoff win since 1992, led by more heroic efforts from Josh Allen. The esteemed Bills quarterback seemed to injure his knee and throwing hand on the same drive early in the game, but that didn’t stop him from accruing 306 total yards and 3 total touchdowns. When it mattered, Trevor Lawrence threw 2 key interceptions, one on the final drive, to seal the Buffalo victory.

As usual, the Allen-led offense was more than effective, answering the call whenever needed. On the other hand, the Bills’ defense played good, not great, only a few times making stops when it mattered. Not ideal was that Jacksonville went 5-9 on 3rd downs and 3-4 in the red zone. In truth, if it wasn’t for Lawrence’s 2 interceptions, the final result might’ve been different. As usual, the onus of Buffalo’s future will remain with Allen and his ability, since we suspect their defense will continue to allow plenty of production from opponents. The Bills will face a much greater challenge this coming Saturday, up in elevation in Denver against a Broncos squad that knows how to win and will be coming off extended rest.

Denver is statistically the opposite of Buffalo. They can rely on their defense, a group that’s top-5 in nearly every metric (including a 1st-place ranking in opponent yards per game, 278.2), but their offense seems to only come alive when they need it. Bo Nix and his colleagues mostly present average to below average marks, particularly in yards per pass, where they generate just 6.4 (29th). This is true even though they own one of the best offensive lines in the NFL, permitting a sack on just 3.62% of plays (2nd overall). The good news for Denver is that they are good under pressure, averaging 7.7 points in the 4th quarter and successfully completing 5 4th-quarter comebacks this season. Of course, Josh Allen and the Bills are also pretty good in this category, too, averaging 9.2 4th-quarter points and earning a few 4th-quarter comebacks themselves.

We’re pretty certain this game will come down to the final drive. Since one of the NFL’s best quarterbacks will be facing one of the NFL’s best defenses, that makes this matchup all the more difficult to predict. At face value, the more rested team at home is generally the side to go with, especially considering their prowess on defense. Personally, we’d love to see Buffalo win, but the intangibles favor Denver.

Bills vs Broncos prediction: Broncos +1 (-110) available at time of publishing. Playable at that number.

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Game Totals Pick

Under 46.5(-110)

Reasoning

The total for this big AFC matchup is in no man’s land, which is not surprising. On the one hand, Denver’s offense produces a healthy 23.6 points per game (14th). If they hope to win, they will likely need to produce more in this battle, which is part of the reason why this total sits at double that amount. Bo Nix is the definition of a momentum-based quarterback, a thrower who can get hot and tends to play his best when under pressure, but it’s far from consistent. It doesn’t help that the Broncos had 313 yards lost to drops this season, which is the 5th-highest in the NFL, and their rushing attack has really fallen off since JK Dobbins went down with an injury in Week 10. Since losing Dobbins, their EPA per rush metrics have dropped from 14th to 25th. Run defense is Buffalo’s biggest weakness, a group that permits 137.2 rush yards per game (28th), so we’re not sure who will have the advantage in that exchange. Contrarily, we are certain that Buffalo has the advantage against the pass, since they rank as a top-5 group in most metrics, including opponent completion percentage, yards per pass, yards per game and interceptions. They can capitalize on Denver’s shortcomings.

This total will likely be decided when Josh Allen and the Bills’ offense is on the field. Denver’s defense, which leads the NFL in sacks (10.29% of plays), will need to contend with one of the league’s best running quarterbacks. Allen needs no introduction, nor do his miraculous playmaking abilities, but it’s important to know how consistent Buffalo’s offense has been this season. Across the board, they are a top-5 group in every category, boasting the 2nd-best marks in yards per rush (4.9), the 3rd-best mark in yards per pass (8.0) and averaging a glorious 28.2 points per game (4th). Of course, Denver’s defense can say the same thing, top-4 or better in all the same defensive metrics.

The Rocky Mountains surrounding the valley that is the city of Denver will look wintry on Saturday, but playing conditions will be rather ideal, 44° and sunny with very little wind. But even on a nice, January Colorado day, defenses usually control these types of battles, and we could see both teams’ offenses coming more alive in the 2nd half. Consider a 2nd-half over if this game starts slow, but we see fewer points overall.

Bills vs Broncos pick: Under 46.5 (-110) available at time of publishing. Playable to 46.

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Chris R. Farley

Why Trust our NFL Picks

At the conclusion of the 2025 regular season, our team of NFL handicappers accumulated 296 wins (and 4 pushes) across sides and totals picks for every game, over those 18 weeks our record speaks for itself. Our expert NFL picks scored +78.1 units of profit throughout the regular season.

NFL Pick	Wins	Push	Losses	Profit (betting units)
Sides (Moneyline/ATS)	151	3	116	+55.4
Totals (Over / Under)	145	1	124	+22.7
Total	296	4	240	+78.1

Regular Season

Our excellent record this season continued through Wild Card Weekend. We had 8 winning against the spread, moneyline and totals picks for the first round of the 2025 NFL Playoffs, adding another +15.2 units profit to our NFL picks this season.

NFL Pick	Wins	Losses	Profit (betting units)
Sides (Moneyline/ATS)	4	2	+6.5
Totals (Over / Under)	4	2	+8.7
Total	8	2	+15.2

Playoffs

At Pickswise, every NFL pick is backed by years of betting experience, advanced data analysis, and a proven track record of success. Our team of handicappers studies line movement, injury reports, historical trends, and matchup stats to deliver informed recommendations — not guesses. We publish our results openly, update our predictions as new information emerges, and never hide behind vague analysis. Whether you’re looking for expert spreads, totals, props, or parlays, our mission is simple: give you honest, well-researched picks that stand up over time.

Free NFL Picks Explained

We firmly believe expert NFL picks should be free, so you’ll find our NFL picks today, and every day of the season, right here. We publish our free NFL picks for every game, at least a few days in advance of gameday, so you know who the experts are backing without missing out on the early value in the betting markets.

There’s almost an infinite way to bet on the NFL, from NFL picks against the spread, moneyline, over/under, NFL Parlays, and NFL Prop Bets, there is a bet type for every kind of football fan, so we provide NFL picks for every bet type. Some bettors like to specialize in a single particular type of NFL pick, while others like to have a diverse range and bet on anything they feel is a value pick.

Here at Pickswise, we have something for everyone. Our team of handicappers have a wealth of experience in making NFL picks across all these betting markets, leaving no stone unturned ahead of every game and every pick of the 2025 NFL season. If you’re looking for more information on NFL bet types, You can find our expert breakdown of each below.

NFL Picks Against the Spread

The most popular way to bet on the NFL is against the spread (ATS). With these wagers, you are not picking a simple winner or loser of a game. Instead, ATS betting is placing your money that Team A wins by a certain amount of points or that Team B will keep the game closer than oddsmakers expect, in other words, not lose by that same amount of points.

For Example

Philadelphia Eagles -7 – Philadelphia must win by 8 or more points to cover the spread.
Chicago Bears +7 – Chicago must win, or lose by 6 or fewer points to cover the spread.
Tie Scenario – If the game ended 27-20 to Philadelphia, the spread would be a tie, or a push and stakes would be returned.

NFL spread betting trends 2025

The team that covers the spread wins the game outright around 80% of the time.
Road teams going into games as the favorite have covered the spread at 64% so far this season
Teams coming off a blowout loss (20+ points) tend to rebound against the spread, 57% of the time.

Free NFL Over / Under Picks

Another exciting way to still get in on the NFL action is with totals wagers. In these bets you don’t take a side, but whether the two teams will combine to score over or under the total number of points that the oddsmakers have set. Already since sports betting has been legalized we’ve seen many occasions where a hail mary, missed FG or XP has cost over or unders bettors, so be prepared to be in for the long haul with your totals bets. We preview every game of the NFL season, providing insight into the game as a whole alongside expert NFL picks so you can make informed NFL totals bets.

NFL over / under betting trends

Overall, unders have proven the value pick in recent seasons, as defenses have caught up with scoring trending down since 2021
Unders bets have the edge in divisional games, landing 57% of the time. This trend gets stronger late in the season (week 13 onwards), especially in cold weather conditions.
Unders bets have landed on 58% of primetime games, as public betting tends to have a bias for the overs in these games.

Money Line NFL Picks

Ask any seasoned NFL bettor and they’ll tell you that ATS betting is exciting, but can also be frustrating. It is important to keep in mind that NFL teams only need to win by one, of course, they’d love to win by more, but they’ll change their schemes late on to secure a win, not to ensure they cover the spread. Your research could have given you the right side, but if they win by 6 instead of 7 your -6.5 bet is a loss. Therefore a lot of bettors like to keep it simple and take our expert NFL Money Line picks and bet on the NFL straight up.

NFL Moneyline betting trends

Through the first 4 weeks of the 2025 season 6+ point favourites have been strong straight up, with a 16-2-1 record
Short underdogs (+1 to +3 on the spread) win outright 43% of the time, offering better value on the moneyline than the spread
Underdogs in lower scoring road games (less than 42 total points) win outright 39% of the time, but often at better prices than this record suggests.

2025-26 NFL Schedule

This will be the 106th season in league history and is set to kick off with the NFL Kick-Off game on Thursday, September 4, hosted by the defending Super Bowl Champions Philadelphia Eagles, who take on the Dallas Cowboys. The regular season will come to a conclusion on January 4, 2026 with the NFL Playoffs scheduled to begin the following weekend on the 10th, 11th & 12th of January 2026. Super Bowl LX is scheduled for February 8, 2026, at Levi’s Stadium in San Francisco, California, the home of the 49ers.

NFL Playoff Picks

You can find our NFL picks for the 2026 Playoffs, right here, for free. Wildcard Weekend is scheduled to start January 10, upon the conclusion of week 18 our experts start to make their picks and predictions for the first round of the playoffs and after each round is concluded we prepare for the coming weekend, all the way up to the Super Bowl.

NFL Playoff Picks
NFL Wildcard Weekend Picks
NFL Divisional Round Picks
NFL Conference Championship Picks

NFL Expert Picks

Our NFL Football picks will be for every game throughout the regular season, with primetime games and the top matchups each week getting additional expert coverage which will extend to every playoff game. These NFL Football picks will come alongside analysis and the latest stats and trends to consider when betting. You can also find our NFL Best Bets for the top plays of the week and a confidence rating for our expert handicapper.

Looking for alternative football picks? then head to our College Football Picks page, where you’ll find the same level of expertise from the Pickswise handicapping team for all the headline games in the 2025 NCAA football season.

More Than Just NFL Football Picks

We also specialize in every major North American sport including the MLB, NBA, NHL, College Football, and College Basketball. Check out our site every day for some of the best bets in every major athletic contest and make sure to follow us on social media as well.

Andrew Wilsher, Managing Editor of Pickswise

Statistical Approach to NFL Picks

It’s our goal to provide you with the best NFL picks in the market. Our expert handicappers are all specially selected and assessed prior to joining the team to ensure their analysis. experience and results are among the best in the industry. Each capper will put hours of research into each pick and many have built statistical models to find their moneyline, spread and over/under picks so you don’t have to. Check out all of our cappers’ free NFL picks here every week of the season.

Andrew Wilsher, Pickswise Managing Editor

NFL Picks FAQs

How Do You Pick Against The Spread In The NFL?

To bet against the spread in the NFL you are either betting the favorite to win by x number of points or the underdog to win, or lose by fewer than x points. For example the Chiefs -7 points or the Panthers +7 points.

The number of points is set by sportsbooks and is often referred to as the line

What Is The Best Website For NFL Picks Against The Spread?

Pickswise is the best website to get free NFL picks against the spread. Our handicappers provide free insight, analysis, and data to back up which way they’re siding against the spread for every NFL game. So far this NFL season our experts have secured 86 winning NFL picks for a profit of 26 units

Where Is The Best Place To Get NFL Picks?

Pickswise is the best place to get free expert NFL picks. We have the best cappers and NFL picks on the market and you can get all of our NFL picks for free! every week.

Each pick is meticulously researched by an experienced NFL handicapper, using our own data, custom-built models, and analytical methods. Our profit this season is 26 units and rising, so don’t miss out on the best NFL picks this week.