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NFL Picks

NFL picks for every game of the 2025-26 season. Our NFL expert picks are informed by key betting trends, statistical analysis and years of NFL betting experience. +44.4 units profit, from 274 winning NFL picks so far this season is the proof.

Our NFL picks this week include against the spread picks for every game in Wild Card Weekend:

Rams vs Panthers

Packers vs Bears

Bills vs Jaguars

49ers vs Eagles

Chargers vs Patriots

Texans vs Steelers

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4:30 PM ET
Sat Jan 10
FOX
Los Angeles Rams
Carolina Panthers
Rams
Panthers
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Point Spread Pick
LA Rams -10.0(-110)

Immediately, several factors are working against the Carolina Panthers in this matchup. Before we get to these factors, we should say that home field advantage has proven to be a significant indicator of playoff success, at least since 2022. Over the past 4 seasons, home teams have gone 18-6 straight up. That being said, and with all due respect to the Carolina Panthers, that might be their only advantage.

That doesn’t mean Carolina can’t win this game. In fact, we’ve seen the Panthers play their best against some of their toughest opponents. One might remember a 30-0 statement in Week 3 after another predictable 0-2 start, a victory that suggested they might not be the same bottom-feeding program we’re used to. They followed with wins against Dallas, at Green Bay, versus Tampa in Week 16 to take control of their own destiny, and a seminal win in Week 13 against the very same Rams. They ran all over Sean McVay’s defense in Week 13, too, piling up 164 on the ground. 

We just have a hard time seeing the same result (or even close) in the Wild Card round. Matthew Stafford, currently leading the odds for MVP, had his worst outing of the year on that fateful Sunday 7 weeks ago. The former Super Bowl champion threw 2 interceptions at crucial parts of the game and lost a fumble on what should have been a game-winning touchdown drive. The Rams’ defense seemed to just take off work, allowing nearly 400 total yards (358) to the usually hapless Panthers. It was the worst we’ve seen LAR all season, which is why we’re confident we won’t see that again on Saturday.

Regression to the mean has a way of swinging back more vicious than it came, and in this instance, we think that’s a very plausible outcome. By every conceivable metric, the Rams are far better than the Panthers. In EPA metrics, the visitors have the 2nd-best offensive rating in the NFL. In the same category, the Panthers rank 26th. Davante Adams, their All-Pro wideout who led the NFL in touchdowns this season, despite missing the last 2 games, is expected to be back for this showdown. Add the retributive element of a rematch and the championship experience of the Rams’ leadership, and we’re anticipating a rare massacre of the home team.

Rams vs Panthers prediction: Rams -10 (-110) available at time of publishing. Playable at that number.

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Game Totals Pick
Over 46.5(-110)

Their Week 13 matchup was a display of offense, but it wasn’t catalyzed by the Rams’ mistakes. Carolina never created points from turnovers. In fact, Stafford’s interceptions suggest even more points should have piled up in their previous battle, since LAR’s mistakes only stymied more production. These are all valid reasons for a relatively high total, the 2nd-highest of Wild Card Weekend, although the playoffs have a way of slowing games down. 

A total of 46.5 also isn’t drastically high considering that we expect the Rams’ offense to respond with ferocity. The market agrees, thus their -10.5 designation. The addition of Davante Adams is a drastic upgrade for an offense that might already have the #1 receiver in the NFL. Despite missing one game, Puka Nacua leads the league in receptions (129) and he’s 2nd in receiving yards (1715). Needless to say, with Stafford playing at an MVP level, we anticipate the Rams displaying massive positive regression against the 22nd-ranked Carolina defense.  

The real question is on Carolina’s side. Clearly, they figured something out in their Week 13 victory over the same enemy. They controlled time of possession (35-25) and were steady when it mattered — 7-15 on 3rd down and 3-3 on 4th. Their 358 total yards were their 4th-most of the season. In general, Bryce Young is a better quarterback at home, both in poise (4 interceptions in Charlotte, 7 elsewhere) and from an efficiency standpoint (66.1% compared to 62.1% on the road). Contrarily, he averaged just 156 passing yards per game in front of his fans.

This number is very sharp but a few ticks too high considering the matchup comforts for both offenses. It helps that Charlotte will present a mild, complementary environment for December football.

Rams vs Panthers pick: Over 46.5 (-110) available at time of publishing. Playable to 47.

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Why Trust our NFL Picks

At the conclusion of the 2025 regular season, our team of NFL handicappers accumulated 296 wins (and 4 pushes) across sides and totals picks for every game, over those 18 weeks our record speaks for itself. Our expert NFL picks have scored +75.2 units of profit so far this season.

NFL PickWinsPushLossesProfit (betting units)
Sides (Moneyline/ATS)1513116+53.5
Totals (Over / Under)1451124+21.7
Total2964240+75.2

At Pickswise, every NFL pick is backed by years of betting experience, advanced data analysis, and a proven track record of success. Our team of handicappers studies line movement, injury reports, historical trends, and matchup stats to deliver informed recommendations — not guesses. We publish our results openly, update our predictions as new information emerges, and never hide behind vague analysis. Whether you’re looking for expert spreads, totals, props, or parlays, our mission is simple: give you honest, well-researched picks that stand up over time.

Free NFL Picks Explained

We firmly believe expert NFL picks should be free, so you’ll find our NFL picks today, and every day of the season, right here. We publish our free NFL picks for every game, at least a few days in advance of gameday, so you know who the experts are backing without missing out on the early value in the betting markets.

There’s almost an infinite way to bet on the NFL, from NFL picks against the spread, moneyline, over/under, NFL Parlays, and NFL Prop Bets, there is a bet type for every kind of football fan, so we provide NFL picks for every bet type. Some bettors like to specialize in a single particular type of NFL pick, while others like to have a diverse range and bet on anything they feel is a value pick.

Here at Pickswise, we have something for everyone. Our team of handicappers have a wealth of experience in making NFL picks across all these betting markets, leaving no stone unturned ahead of every game and every pick of the 2025 NFL season. If you’re looking for more information on NFL bet types, You can find our expert breakdown of each below.

NFL Picks Against the Spread

The most popular way to bet on the NFL is against the spread (ATS). With these wagers, you are not picking a simple winner or loser of a game. Instead, ATS betting is placing your money that Team A wins by a certain amount of points or that Team B will keep the game closer than oddsmakers expect, in other words, not lose by that same amount of points.

For Example

Philadelphia Eagles -7 – Philadelphia must win by 8 or more points to cover the spread.
Chicago Bears +7 – Chicago must win, or lose by 6 or fewer points to cover the spread.
Tie Scenario – If the game ended 27-20 to Philadelphia, the spread would be a tie, or a push and stakes would be returned.

  • The team that covers the spread wins the game outright around 80% of the time.
  • Road teams going into games as the favorite have covered the spread at 64% so far this season
  • Teams coming off a blowout loss (20+ points) tend to rebound against the spread, 57% of the time.

Free NFL Over / Under Picks

Another exciting way to still get in on the NFL action is with totals wagers. In these bets you don’t take a side, but whether the two teams will combine to score over or under the total number of points that the oddsmakers have set. Already since sports betting has been legalized we’ve seen many occasions where a hail mary, missed FG or XP has cost over or unders bettors, so be prepared to be in for the long haul with your totals bets. We preview every game of the NFL season, providing insight into the game as a whole alongside expert NFL picks so you can make informed NFL totals bets.

  • Overall, unders have proven the value pick in recent seasons, as defenses have caught up with scoring trending down since 2021
  • Unders bets have the edge in divisional games, landing 57% of the time. This trend gets stronger late in the season (week 13 onwards), especially in cold weather conditions.
  • Unders bets have landed on 58% of primetime games, as public betting tends to have a bias for the overs in these games.

Money Line NFL Picks

Ask any seasoned NFL bettor and they’ll tell you that ATS betting is exciting, but can also be frustrating. It is important to keep in mind that NFL teams only need to win by one, of course, they’d love to win by more, but they’ll change their schemes late on to secure a win, not to ensure they cover the spread. Your research could have given you the right side, but if they win by 6 instead of 7 your -6.5 bet is a loss. Therefore a lot of bettors like to keep it simple and take our expert NFL Money Line picks and bet on the NFL straight up.

  • Through the first 4 weeks of the 2025 season 6+ point favourites have been strong straight up, with a 16-2-1 record
  • Short underdogs (+1 to +3 on the spread) win outright 43% of the time, offering better value on the moneyline than the spread
  • Underdogs in lower scoring road games (less than 42 total points) win outright 39% of the time, but often at better prices than this record suggests.

2025-26 NFL Schedule 

This will be the 106th season in league history and is set to kick off with the NFL Kick-Off game on Thursday, September 4, hosted by the defending Super Bowl Champions Philadelphia Eagles, who take on the Dallas Cowboys. The regular season will come to a conclusion on January 4, 2026 with the NFL Playoffs scheduled to begin the following weekend on the 10th, 11th & 12th of January 2026. Super Bowl LX is scheduled for February 8, 2026, at Levi’s Stadium in San Francisco, California, the home of the 49ers.

NFL Playoff Picks

You can find our NFL picks for the 2026 Playoffs, right here, for free. Wildcard Weekend is scheduled to start January 10, upon the conclusion of week 18 our experts start to make their picks and predictions for the first round of the playoffs and after each round is concluded we prepare for the coming weekend, all the way up to the Super Bowl.

NFL Playoff Picks
NFL Wildcard Weekend Picks
NFL Divisional Round Picks
NFL Conference Championship Picks

NFL Expert Picks

Our NFL Football picks will be for every game throughout the regular season, with primetime games and the top matchups each week getting additional expert coverage which will extend to every playoff game. These NFL Football picks will come alongside analysis and the latest stats and trends to consider when betting. You can also find our NFL Best Bets for the top plays of the week and a confidence rating for our expert handicapper.

Looking for alternative football picks? then head to our College Football Picks page, where you’ll find the same level of expertise from the Pickswise handicapping team for all the headline games in the 2025 NCAA football season.

More Than Just NFL Football Picks

We also specialize in every major North American sport including the MLB, NBA, NHL, College Football, and College Basketball. Check out our site every day for some of the best bets in every major athletic contest and make sure to follow us on social media as well.

Andrew Wilsher, Managing Editor of Pickswise

Statistical Approach to NFL Picks

It’s our goal to provide you with the best NFL picks in the market. Our expert handicappers are all specially selected and assessed prior to joining the team to ensure their analysis. experience and results are among the best in the industry. Each capper will put hours of research into each pick and many have built statistical models to find their moneyline, spread and over/under picks so you don’t have to. Check out all of our cappers’ free NFL picks here every week of the season. 

Andrew Wilsher, Pickswise Managing Editor

NFL Picks FAQs

To bet against the spread in the NFL you are either betting the favorite to win by x number of points or the underdog to win, or lose by fewer than x points. For example the Chiefs -7 points or the Panthers +7 points.

The number of points is set by sportsbooks and is often referred to as the line

 

Pickswise is the best website to get free NFL picks against the spread. Our handicappers provide free insight, analysis, and data to back up which way they’re siding against the spread for every NFL game. So far this NFL season our experts have secured 86 winning NFL picks for a profit of 26 units

Pickswise is the best place to get free expert NFL picks. We have the best cappers and NFL picks on the market and you can get all of our NFL picks for free! every week.

Each pick is meticulously researched by an experienced NFL handicapper, using our own data, custom-built models, and analytical methods. Our profit this season is 26 units and rising, so don’t miss out on the best NFL picks this week.