NFL Week 1 Picks, Predictions & Betting Lines
The home of our free Week 1 NFL Picks and Predictions. Our expert NFL handicappers research the entire NFL Week 1 schedule, to bring you the best NFL expert picks this week. For full expert analysis, insight, and all of our Week 1 NFL picks and Predictions, be sure to check out some of our most popular NFL pages including our NFL Picks, and NFL Predictions, alongside our NFL Prop Bets and NFL Parlays today.
| Thursday, Sept. 7 | Spread Pick |
| Detroit Lions vs. Kansas City Chiefs | Lions +6.5 |
| Sunday, Sept. 10 | Spread Pick |
| Carolina Panthers vs. Atlanta Falcons | Falcons -3.5 |
| Tampa Bay Buccaneers vs. Minnesota Vikings | Vikings -6 |
| Cincinnati Bengals vs. Cleveland Browns | Browns +2.5 |
| Jacksonville Jaguars vs. Indianapolis Colts | Jaguars -5 |
| San Francisco 49ers vs. Pittsburgh Steelers | Steelers +2.5 |
| Tennessee Titans vs. New Orleans Saints | Saints -3 |
| Arizona Cardinals vs. Washington Commanders | Cardinals +7 |
| Houston Texans vs. Baltimore Ravens | Ravens -10 |
| Philadelphia Eagles vs. New England Patriots | Eagles -4 |
| Las Vegas Raiders vs. Denver Broncos | Raiders +3.5 |
| Miami Dolphins vs. Los Angeles Chargers | Chargers -3 |
| Los Angeles Rams vs. Seattle Seahawks | Rams +5 |
| Green Bay Packers vs. Chicago Bears | Packers +1.5 |
| Dallas Cowboys vs. New York Giants | Cowboys -3.5 |
| Monday, Sept. 11 | Spread Pick |
| Buffalo Bills vs. New York Jets | Bills -2.5 |
NFL Odds Week 1
With many different NFL betting sites available, it’s important to shop the odds and lines each game week. Check out the best NFL Week 1 odds from the Top Online Sportsbooks below. You can find all of the NFL Week 1 Money line odds, Week 1 NFL Spreads, and Week 1 NFL Total’s.
NFL Week 1 Spreads, Money Line Odds & Over Under Points Totals
Check out the NFL Week 1 Spreads and Money Line favorites at all of the best online sportsbooks below.