NFL Week 16 Picks Against The Spread & Straight Up For 2020

NFL week sixteen picks against the spread and straight up for every game this week. Get our free NFL week sixteen expert picks below. Get free NFL picks every week of the season.

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NFL Week 16 Picks Against The Spread & Straight Up For 2020

The home of our free NFL Picks and Predictions for week 16 of the 2020-21 NFL season.

Our expert NFL handicappers, research the entire NFL Week 16 schedule to bring you the best week 16 NFL picks, predictions, and best bets.

The penultimate week of the regular season, with no teams on a bye week, and playoff implications all around, Week 16 is always one of the most exciting, but toughest weeks of the calendar. Week 16 sees a full 16-game slate, giving us maximum opportunity to finish strong and find some more hidden gems. This page contains everything week 16, including the NFL week 16 spreads, betting lines, Moneyline odds, and our week 16 NFL picks and predictions.

Our expert NFL handicappers research, analyze, and preview every game to find you the best free Picks and NFL Betting lines for week 16.

NFL Week 16 Schedule –  NFL Games Week 16

Friday, Dec. 25 – Christmas Day Game 

4:30 p.m ET – Minnesota Vikings at New Orleans Saints

Saturday, Dec. 26

1 p.m. ET – Tampa Bay Buccaneers at Detroit Lions
3:30 p.m. ET – San Francisco 49ers at Arizona Cardinals
8:15  p.m. ET – Miami Dolphins at Las Vegas Raiders

Sunday, Dec. 27

1 p.m. ET – New York Giants at Baltimore Ravens
1 p.m. ET – Cincinnati Bengals at Houston Texans
1 p.m. ET – Chicago Bears at Jacksonville Jaguars
1 p.m. ET – Cleveland Browns at New York Jets
1 p.m. ET – Atlanta Falcons at Kansas City Chiefs
1 p.m. ET – Indianapolis Colts at Pittsburgh Steelers
1 p.m. ET – Carolina Panthers at Washington Football Team
4:05 p.m. ET – Denver Broncos at Los Angeles Chargers
4:25 p.m. ET – Los Angeles Rams at Seattle Seahawks
4:25 p.m. ET – Philadelphia Eagles at Dallas Cowboys
8.20 p.m. ET – Tennessee Titans at Green Bay Packers

Monday, Dec. 28

8.15 p.m. ET –Buffalo Bills at New England Patriots (Monday Night Football)

NFL Odds Week 16

Our experts look through the entire Week 16 schedule and Week 16 odds, to find the best Week 16 NFL picks.

There are many different betting markets to choose from when wagering on a match, and while our main focus here is on the three most popular markets among NFL bettors – Moneyline, Against the Spreads, and Points Totals, be sure to check out our NFL Parlays and NFL Prop Bets for our best alternative NFL Week 16 predictions.

NFL Week 16 Spreads and Moneyline Favorites

Friday, Dec. 25 – Christmas Day Game 

4:30 p.m ET – Minnesota Vikings at New Orleans Saints -7

Saturday, Dec. 26

1 p.m. ET – Tampa Bay Buccaneers -9.5 at Detroit Lions
3:30 p.m. ET – San Francisco 49ers at Arizona Cardinals -4.5
8:15  p.m. ET – Miami Dolphins -2.5 at Las Vegas Raiders

Sunday, Dec. 27

1 p.m. ET – New York Giants at Baltimore Ravens -10.5
1 p.m. ET – Cincinnati Bengals at Houston Texans -8.5
1 p.m. ET – Chicago Bears -7.5 at Jacksonville Jaguars
1 p.m. ET – Cleveland Browns -9.5 at New York Jets

1 p.m. ET – Atlanta Falcons at Kansas City Chiefs -11
1 p.m. ET – Indianapolis Colts -1.5 at Pittsburgh Steelers
1 p.m. ET – Carolina Panthers at Washington Football Team -2
4:05 p.m. ET – Denver Broncos at Los Angeles Chargers -3

4:25 p.m. ET – Los Angeles Rams at Seattle Seahawks -2
4:25 p.m. ET – Philadelphia Eagles -2 at Dallas Cowboys
8.20 p.m. ET – Tennessee Titans at Green Bay Packers -3.5

Monday, Dec. 28

8.15 p.m. ET –Buffalo Bills-6.5  at New England Patriots (Monday Night Football)

Over-under NFL Week 16 Betting Lines

Friday, Dec. 25 – Christmas Day Game 

4:30 p.m ET – Minnesota Vikings at New Orleans Saints O/U 51.5

Saturday, Dec. 26

1 p.m. ET – Tampa Bay Buccaneers at Detroit Lions O/U 54
3:30 p.m. ET – San Francisco 49ers at Arizona Cardinals O/U 49
8:15  p.m. ET – Miami Dolphins at Las Vegas Raiders O/U 47.5

Sunday, Dec. 27

1 p.m. ET – New York Giants at Baltimore Ravens O/U 45
1 p.m. ET – Cincinnati Bengals at Houston Texans O/U 45.5
1 p.m. ET – Chicago Bears at Jacksonville Jaguars O/U 47
1 p.m. ET – Cleveland Browns at New York Jets O/U 46
1 p.m. ET – Atlanta Falcons at Kansas City Chiefs O/U 53.5
1 p.m. ET – Indianapolis Colts at Pittsburgh Steelers O/U 44.5
1 p.m. ET – Carolina Panthers at Washington Football Team O/U 44.5
4:05 p.m. ET – Denver Broncos at Los Angeles Chargers O/U 48.5
4:25 p.m. ET – Los Angeles Rams at Seattle Seahawks O/U 47.5
4:25 p.m. ET – Philadelphia Eagles at Dallas Cowboys O/U 49.5
8.20 p.m. ET – Tennessee Titans at Green Bay Packers O/U 56.5

Monday, Dec. 28

8.15 p.m. ET –Buffalo Bills at New England Patriots O/U 45

Key Week 16 NFL Matchups To Watch

Tennessee Titans at Green Bay Packers, Sunday 8.20 p.m. ET – Packers -3.5, O/U 56.5

NFL fans are in for a treat on Sunday Night Football in Week 16 as the 10-4 Tennessee Titans head to a frosty Lambeau Field to take on the 11-3 Green Bay Packers. Aaron Rodgers is playing as well as he ever has done this season, already surpassing 40 passing TD’s on the year and firmly in the race for the MVP award. Tennessee Titans have a star of their own on offense, the wrecking ball that is Derrick Henry. Henry leads the league in rushing yards this year, as he did last season, currently sitting on 1,679 rushing yards with two games to play, a 2,000-yard season isn’t out of the picture. Henry will be key as usual for the Titans’ chances against what is an improved run defense from a year ago, with the Packers conceding the 11th fewest rushing yards per game in the league with 110.1.  The Titans have conceded the fourth most Passing Yards (3864) and fourth-most Passing Touchdowns (30) this season, so Aaron Rodgers & Co who are humming right now will be confident of keeping the ball rolling here in a match that will have playoff and seeding implications for both sides.