Chicago Cubs

Chicago Cubs vs San Diego Padres Prediction, Odds and Picks for Today, 04/27/26

Petco ParkMARQ, SDPA
Cubs
17-11
Cubs
Today
Padres
18-9
Padres
San Diego Padres
Google News

Cubs vs Padres Pickswise Expert Predictions

Money Line Pick
SD Padres Win(-105)

The Chicago Cubs take I-5 south from Los Angeles to San Diego to open a 3-game set with the Padres at Petco Park. The Cubs roll out LHP Matthew Boyd, who is 1-1 with a 5.79 ERA in 3 starts, and this will be his first road start of the season. The Padres are 5-2 against left-handed starting pitchers so far this season, so it’s a hard landing spot for the southpaw Boyd to make his first outing away from the Friendly Confines.

The Cubs had their 10-game winning streak come to a close Saturday, as the Dodgers crushed them 12-4, and they followed that up with a 6-0 loss to L.A., as LHP Shota Imanaga was no match for the Dodgers lineup. And, just like that, Chicago pitching has allowed at least 4 runs in as many games, giving up an average of 7.3 runs per game, with the Over going 5-1 in the past 6 games for the Cubs, in case you’re looking for a same-game parlay opportunity. The Padres split a pair of games in Mexico City, and they’ll be glad to be back at sea level after playing three games in Denver prior to that. Let’s go with the Padres to keep up the good work at the plate, taking care of Boyd and the Cubs.

Cubs vs Padres prediction: Padres ML (-105) available at time of publishing. Playable to -120.

If you’re looking for a new sportsbook, check out bet365, the world’s #1 sportsbook. They have an amazing sign-up offer where you can INSTANTLY receive $200 in bonus bets from a $10 wager, regardless of whether that bet wins or loses! There’s no catch, it’s really that simple. Join Bet365 right now ⏰ in time to fade or follow our experts’ Cubs vs Padres predictions.

Photo of Joe Williams

Joe Williams

College basketball and MLB expert for Pickswise with 10+ years of handicapping experience. For Joe Williams media enquiries, please email contact@pickswise.com.
Read more about Joe Williams