Chicago Cubs vs San Diego Padres Prediction, Odds and Picks for Today, 04/27/26

The Chicago Cubs take I-5 south from Los Angeles to San Diego to open a 3-game set with the Padres at Petco Park. The Cubs roll out LHP Matthew Boyd, who is 1-1 with a 5.79 ERA in 3 starts, and this will be his first road start of the season. The Padres are 5-2 against left-handed starting pitchers so far this season, so it’s a hard landing spot for the southpaw Boyd to make his first outing away from the Friendly Confines.

The Cubs had their 10-game winning streak come to a close Saturday, as the Dodgers crushed them 12-4, and they followed that up with a 6-0 loss to L.A., as LHP Shota Imanaga was no match for the Dodgers lineup. And, just like that, Chicago pitching has allowed at least 4 runs in as many games, giving up an average of 7.3 runs per game, with the Over going 5-1 in the past 6 games for the Cubs, in case you’re looking for a same-game parlay opportunity. The Padres split a pair of games in Mexico City, and they’ll be glad to be back at sea level after playing three games in Denver prior to that. Let’s go with the Padres to keep up the good work at the plate, taking care of Boyd and the Cubs.

Cubs vs Padres prediction: Padres ML (-105) available at time of publishing. Playable to -120.

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