Cleveland Guardians vs Detroit Tigers Prediction, Odds and Picks for Today, 05/21/26

The Tigers continued their losing ways with a crushing 3-2 loss in 10 innings to the Guardians on Wednesday night. Detroit held a 1-0 lead going into the 9th and looked to be on the verge of picking up a much-needed win. However, Cleveland crawled its way back to tie the game in the 9th and eventually won it in extras. The loss is just the latest demoralizing defeat for the Tigers, who have now dropped 5 games in a row and are just 2-13 over their last 15 contests. On the other side, the Guardians have won 5 games in a row and 8 of their last 9 as they look to complete the 4-game series sweep on Thursday afternoon at Comerica Park.

Casey Mize is slated to take the mound for the Tigers, and he will be making his 2nd start since coming off the IL with a right adductor strain. He’s been effective when healthy, but the offense supporting him is tough to trust at this point in time. The Tigers have been held to just 2.2 runs per game over their last 9 contest. Furthermore, they are just 2-5 in Mize’s 7 starts this season. All in all, the Tigers are not a team to be backing right now. The Guardians are rolling, and they should be able to find the win column again in this one.

Guardians vs Tigers prediction: Guardians ML (-105) available at time of publishing. Playable to -110.