Houston Astros vs Baltimore Orioles Prediction, Odds and Picks for Today, 04/29/26

Game 2 of this three-game set between the Houston Astros and Baltimore Orioles will be played on Wednesday night. The Orioles won the first game by a score of 5-3. The Astros are no strangers to high-scoring games. They have the fifth-ranked offense in the MLB, averaging 5.2 runs per game. On the flip side of this, they give up the most runs in the entire league, averaging 6.0 runs per game. They will be going up against Chris Bassitt who is projected to get the start for the Orioles. Bassitt has not been good this season. He has a 6.75 ERA in 21.1 innings pitched. He has walked more batters than he has struck out and he got tagged for five runs in his last outing, including two home runs. Look for the Astros to score a few on him.

To stay in this game, the Orioles are going to have to score some runs. Bassitt is going to give up his share, so the bats will need to be working. All signs are pointing towards a high-scoring game. Give me the over in this one.

Astros vs. Orioles prediction: Over 9 (-105) available at time of publishing. Playable at that number.