Houston Astros vs Minnesota Twins Prediction, Odds and Picks for Today, 05/19/26

The Minnesota Twins secured a 6-3 victory over the Houston Astros last night and will look to keep the momentum rolling behind starter Zebby Mathews. Matthews was impressive in his first start of the season, tossing seven scoreless innings while striking out five against the Miami Marlins. For the Astros, they’ll hand the ball over to Lance McCullers who has struggled this season, entering with a 2-3 record, 6.86 ERA, and a 1.53 WHIP through eight starts. The Twins started off the season slow, but they’ve now won six of their last ten games while the Astros have struggled, losing seven of their last 10.

In that same span, the Twins are averaging 4.2 runs per game and hitting .241 compared to the Astros who are averaging 2.0 runs per game and batting .192. Given the Twins recent form, they should have no issues against the Astros tonight. For the Twins, they have players like Luke Keaschall, who’s batting .263 and Austin Martin hitting .255 in their last 12 games. Another promising sign for this Twins offense is Josh Bell who’s batting .234 with two home runs and 11 RBIs in that same span. For the Astros, their best player is Yordan Alvarez who’s hitting .289 with three home runs and four RBIs in his last 14 games. Other than that, Matthews won’t have to worry too much about other hitters like Christian Walker who’s batting .140 and Cam Smith who’s hitting .105 in that same span. The Astros haven’t been able to find anything going offensively all season, and I don’t expect that to change tonight. Look for the Twins to pick up another win as they rally behind Matthews in tonight’s matchup.

Astros vs Twins prediction: Twins ML (-140) at the time of publishing. Playable up to – 165.