Los Angeles Angels vs Cleveland Guardians Prediction, Odds and Picks for Today, 05/12/26

The Los Angeles Angels were tripped up in the series opener at Progressive Field on Monday against the Cleveland Guardians, falling 7-2. The Angels had an opener, and it was a bullpen game, and it went poorly, with the first 3 pitchers allowing at least 2 earned runs while lasting 1 2/3 IP or less, including 2 guys who retired just 2 batters apiece. The Angels were able to collect nine hits on the night, but they couldn’t string them together. RF Jo Adell did stay hot, going 2 for 4 with a double and an RBI, and he is one to watch on Tuesday.

The Guardians turn to RHP Slade Cecconi for Tuesday’s start, but it’s been a tough go for him this season. He is 2-4 with a 6.15 ERA and 1.59 WHIP across this eight starts. He has been slightly better at home, going 0-1 with a 4.91 ERA in two outings, but home runs have been his downfall. He has allowed two homers in two home starts, and 6 across his road outings. With Adell, Nolan Schanuel and others playing well for the Angels, it is going to be a tall order for the Guardians’ right-hander. Look for the Halos to exact a little revenge Tuesday.

Angels vs Guardians prediction: Angels ML (+120) at time of publishing. Playable to +110.

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