San Francisco Giants vs The Athletics Prediction, Odds and Picks for Today, 05/16/26

The former battle of the Bay Area takes center stage on MLB’s rivalry weekend, as the San Francisco Giants are in Sacramento to take on the Athletics. The Athletics took the first game of the series 5-2 on Friday night, which is unsurprising given the Giants’ recent struggles, who are 4-6 over their past 10 and nine games under .500. Things have been going better for the Athletics, who are currently leading the American League West as the only team there over .500.

Trevor McDonald takes the mound for the Giants for his third start of the season after going back and forth between San Francisco and their AAA affiliate in Sacramento. San Francisco’s starter will be right at home for this outing and has been performing well for the Giants this season, allowing just four earned runs over 12.1 innings.

Luis Severino has also settled in for the Athletics this season, allowing just five earned runs over his last four starts. After a rough start to the season, his ERA has been slowly declining, and he has been looking like his old self. The wins haven’t been there thanks to a lack of run support, but it’s definitely something to build on.

The pitchers should settle in for this matchup, and we get another low-scoring game after last night’s seven-run result.

Giants vs Athletics prediction: Under 9.5 (-105) available at time of publishing. Playable to that number.