St. Louis Cardinals vs San Diego Padres Prediction, Odds and Picks for Today, 05/10/26

The San Diego Padres will host the St. Louis Cardinals on Sunday for the 4th and final game of their weekend series. They will be looking to split the series with a win, as the Cardinals have won 2 of the first 3 games. They go up against Kyle Leahy, who will take the mound for the Cardinals. He has been average at best this season, with a 4.93 ERA in 34.2 innings pitched. In 3 of his last 4 starts, he gave up at least 3 earned runs.

The Padres will counter with Walker Buehler, who has struggled to say the least. He has a 5.64 ERA across 30.1 innings, and in 2 of his last 3 starts, he gave up 4 or more earned runs.

These are 2 good offensive teams; the Cardinals average 4.7 runs per game, while the Padres average 4.3. I expect those trends to continue in a high-scoring game on Sunday afternoon. Look for the power bats in these lineups to do some damage against these struggling starting pitchers. Give me the over in this one.

Cardinals vs. Padres prediction: Over 8.5 (+100) available at time of publishing. Playable to -110.

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