The Athletics vs San Diego Padres Prediction, Odds and Picks for Today, 05/22/26

The Athletics will look to stay hot offensively when they head to San Diego for a matchup against the Padres. The A’s have won 3 straight games and 5 of their last 10 overall, while the Padres have dropped back-to-back games despite winning 6 of their last 10. Taking the mound for the A’s will be the left-hander Jeffrey Springs, who is 3-4 with a 3.93 ERA. Meanwhile, the Padres will hand the ball to Walker Buehler, who is 3-2 with a 5.01 ERA. 

The Athletics have clearly been the hotter offense lately, averaging 4.8 runs per game while batting .250 over their last 10. In comparison, the Padres offense continues to struggle, averaging just 3.3 runs per game and hitting only .203 during that same stretch. The Padres have also had major issues against left-handed pitching this season, batting just .216 against southpaws — which puts them in a difficult spot against Springs.

Season-long numbers also favor the A’s offensively. The A’s rank near the top of the league in batting average (.249), while San Diego is in last (.221). Though the Padres hold an edge in the bullpen department with a 3.32 ERA compared to the A’s at 4.44, the Athletics should be able to do enough offensively early on against Buehler. Look for the A’s to outpower the Padres and extend their winning streak to 4 games. 

Athletics vs Padres prediction: Athletics ML (+110) at the time of publishing. Playable up to – 105. 

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