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Best NFL Week 2 underdog picks

Best NFL Week 2 underdog picks

Andrew Ortenberg
Andrew OrtenbergAuthor
UpdatedApr 29, 2026
Reading time3 min

There’s nothing better than an upset in pro sports, and it doesn’t hurt that there’s often value betting NFL underdogs. Things are up in the air during the 2020 season more than ever, which should lead to some truly wild outcomes.

We already saw a few big upsets in Week 1 with teams like the Jaguars, Washington, and Cardinals, and today we’ll be bringing you our favorite NFL underdog picks for Week 2:

1. Dolphins +5.5 vs. Bills

I think the Dolphins are going to walk away with an outright win here. The Bills beat the Jets in Week 1, but I wasn’t too impressed given the current state of New York’s team. Buffalo wasn’t efficient on offense, and they got absolutely nothing going on the ground with either Devin Singletary or Zack Moss.

Playing in the humid Florida heat gives the Dolphins a big edge as their players are used to it, and Ryan Fitzpatrick is due for a nice bounce back in this revenge spot against his former team. This Bills defense isn’t going to be as good as it was last year after losing guys like Jordan Phillips and Lorenzo Alexander, and there’s no way I could lay a spread this large with Josh Allen on the road.

2. Jets +7 vs. 49ers

Speaking of the Jets, you have to back them this week even though it won’t feel great. This is a chance to buy them at the bottom of the market, and they should come out angry after all the flak they’ve been catching this week in the media. I’m expecting an inspired effort, and this 49ers team clearly isn’t as good as it was last year.

They lost to Arizona as huge favorites in Week 1 even though the Cardinals played far from a great game. Jimmy Garoppolo is lost the moment things go off script, and now George Kittle is dealing with a knee injury that will at least limit his effectiveness in this game. I don’t expect a blowout at all here.

3. Patriots +4 @ Seahawks

All eyes were on Cam Newton this past week in his Patriots debut, and he certainly met expectations and then some. He was nearly unstoppable as a runner, and Seattle’s linebackers aren’t going to be able to keep up with him. Seattle had the luxury of going against Atlanta’s barely-there defense in their opener, and now facing this tough New England unit will come as a shock to their system.

Speaking of shocks to their system, Seattle usually has one of the noisiest crowds in the NFL, but that won’t be the case here. The Seahawks are hurt disproportionately by the lack of fans since they normally have such a great home field advantage. I think Seattle offensive coordinator Brian Schottenheimer will regress to his old conservative ways here, and New England will come out on top.

For the best NFL underdog picks all season long, make sure to check out our NFL underdog picks!

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