The first edition of Thursday Night Football on Amazon Prime will feature one of the highest totals we'll likely see all season at 54.5 points. Both the Lions and Bills come in 1-0, fresh off dramatic victories. Josh Allen is the current MVP betting favorite, while Jahmyr Gibbs headlines the AP Offensive Player of the Year race.
Let's dive into my best Lions vs Bills anytime touchdown scorer picks for TNF, while you can also get our expert NFL picks for every game in Week 2 and throughout the entire 2026 season.
Odds available at BetMGM Sportsbook at time of publishing.
Amon-Ra St. Brown started his 2026 campaign with a stat-stuffing performance. He found the endzone twice, both within the redzone. The Bills' secondary was torched in Week 1, allowing C.J. Stroud to throw for 274 yards, and more importantly, Nico Collins to erupt for 75 yards on 7 receptions and a touchdown.
After ranking in the top 5 in target share last year at 31.3%, St. Brown looks to increase that after a 35.9% target share in Week 1. In particular, last season, St. Brown was targeted in the redzone 33 times at a 37.5% rate - tied with Davante Adams for most targets inside the 20-yard line. Expect another massive week from St. Brown in one of the most anticipated scoring games of the season.
Find out Prop Holliday's best Lions vs Bills player prop bets
Odds available at DraftKings Sportsbook at time of publishing.
Good luck finding any value for touchdown bets for Thursday Night. With a 54.5 total, 6 players have shorter odds than +200 to score a touchdown. So, we'll take a shot at the Bills' defense or special teams lucking into a touchdown. Last week versus the Saints, Jared Goff was sacked by Chase Young and returned for a touchdown. But after further review, it was ruled an incomplete pass, prompting many to question the call. Nonetheless, the Bills registered two fumble recoveries and three sacks versus a revamped Texans offensive line. Let's take our shot at +650!
Check out our expert's Lions vs Bills Same Game Parlay for TNF at +950!
