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College football betting guide: Expert Week 6 CFB predictions, picks, odds & best bets

College football betting guide: Expert Week 6 CFB predictions, picks, odds & best bets

Andrew Wilsher
Andrew WilsherAuthor
UpdatedSep 15, 2026
Reading time2 min

We’re approaching the midway point of the 2024 college football season as we’ve reach Week 6 and have another huge batch of great matchups to get excited for. Here at Pickswise, our team of expert CFB handicappers have EVERY big game covered for Saturday’s mega slate, and you can find out all of our college football picks and CFB predictions for those matchups. On top of that, we have our top experts’ best bets of the day, along with our parlays and Same Game Parlay picks to help you bet better today across all of the NCAAF action. Let’s dive in!

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College football Week 6 best bets

Our top college football expert gives their best bets across Saturday’s huge slate.

College football Week 6 parlays

See our CFB Week 6 parlay for Saturday’s games, while we have an SGPs for the big conference matchup between the Iowa Hawkeyes and Ohio State Buckeyes.

We recommend using Bet365 if you’re looking to bet on our college football parlay and Iowa vs Ohio State Same Game Parlay, where you’ll find some of the best odds available. Not got a Bet365 account? No problem! Simply click here to join and you’ll INSTANTLY receive $200 in bonus bets when you make a first bet of just $5!

College football Week 6 picks

Below, you’ll find our betting previews and NCAAF predictions for the hottest matchups in Week 6:

  • Missouri vs Texas A&M prediction
  • SMU vs Louisville prediction
  • Auburn vs Georgia prediction
  • Indiana vs Northwestern prediction
  • Iowa vs Ohio State prediction
  • Ole Miss vs South Carolina prediction
  • Rutgers vs Nebraska prediction
  • Alabama vs Vanderbilt prediction
  • Clemson vs Florida State prediction
  • Baylor vs Iowa State prediction
  • Michigan vs Washington prediction
  • Tennessee vs Arkansas prediction
  • Miami vs California prediction
  • Texas Tech vs Arizona prediction
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