NFL betting guide: Expert 2022 Week 16 NFL picks, predictions, odds & best bets

Bills receiver Stefon Diggs makes a catch over the middle against the Miami Dolphins
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Phil Agius


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I've been writing about the NFL and a host of other sports for the UK's top daily betting paper the Racing Post for more than 20 years. An incurable Browns fan (1-31 survivor), I also specialise in all kinds of motorsport betting including F1, MotoGP, IndyCar and NASCAR. For Phil Agius media enquiries, please email

Welcome to the Pickswise NFL Week 16 betting guide! Someone on the nice list must have ordered a bunch of NFL snow games for Christmas because the weather could play a major role in the holiday weekend slate.

Week 16 kicked off with a win for the Jaguars against the Jets, and we have 11 Christmas Eve games on Saturday and 3 on Christmas Day itself on Sunday, with a Monday game to watch as you wolf down the leftovers on Monday too — they’ve thought of everything.

Saturday’s 1:00pm slate could see some of the wildest weather, most likely at the Bills vs Bears, Saints vs Browns, Texans vs Titans and Bengals vs Patriots games, so wrap up warm if you’re watching NFL RedZone!

The late afternoon slate is NFC East-heavy with Commanders vs 49ers and Eagles vs Cowboys, while Santa will be loading up his sleigh by the time the Raiders meet the Steelers on Saturday Night Football at 8:15pm ET.

Our experts have done the hard work so you have everything you need to bet better and get the right results. This is your one-stop shop for everything you need to make the most of your NFL weekend — and Monday night’s Chargers vs Colts game. Don’t forget to check out our great NFL predictions for every game on the Week 16 slate.

NFL Week 16 picks

NFL Week 16 expert betting picks and predictions

NFL Week 16 prop bets

NFL Week 16 Promo Codes

Find all the latest Sportsbook Promo Codes and Bonuses for NFL Week 16, including sportsbooks live in your state.

NFL Week 16 big-game predictions

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