NFL betting guide: Expert 2022 Week 16 NFL picks, predictions, odds & best bets
Welcome to the Pickswise NFL Week 16 betting guide! Someone on the nice list must have ordered a bunch of NFL snow games for Christmas because the weather could play a major role in the holiday weekend slate.
Week 16 kicked off with a win for the Jaguars against the Jets, and we have 11 Christmas Eve games on Saturday and 3 on Christmas Day itself on Sunday, with a Monday game to watch as you wolf down the leftovers on Monday too — they’ve thought of everything.
Saturday’s 1:00pm slate could see some of the wildest weather, most likely at the Bills vs Bears, Saints vs Browns, Texans vs Titans and Bengals vs Patriots games, so wrap up warm if you’re watching NFL RedZone!
The late afternoon slate is NFC East-heavy with Commanders vs 49ers and Eagles vs Cowboys, while Santa will be loading up his sleigh by the time the Raiders meet the Steelers on Saturday Night Football at 8:15pm ET.
Our experts have done the hard work so you have everything you need to bet better and get the right results. This is your one-stop shop for everything you need to make the most of your NFL weekend — and Monday night’s Chargers vs Colts game. Don’t forget to check out our great NFL predictions for every game on the Week 16 slate.
NFL Week 16 picks
- NFL picks against the spread and total for EVERY Week 16 game
- NFL best bets – we have a 47-32 record on our 3-star plays this season
- NFL parlays
NFL Week 16 expert betting picks and predictions
- Jared Smith’s Week 16 best bets
- NFL Week 16 mega parlay (+914 odds!)
- Week 16 best bets on Prophet Exchange
- Week 16 millionaire maker 14-team parlay
- Packers vs Dolphins Same Game Parlay
- Rams vs Broncos Same Game Parlay
- Buccaneers vs Cardinals Same Game Parlay
NFL Week 16 prop bets
- Saturday NFL player props – from Prop Holliday — we went 11-5 on NFL props in Week 15!
- ThriveFantasy Week 16 player props
- Best touchdown scorer bets for Week 16
- Best Packers vs Dolphins touchdown scorer bets
- Best Buccaneers vs Cardinals touchdown scorer bets
NFL Week 16 Promo Codes
- BetMGM Promo Code: Bet $10 Win $200 if either NFL Team scores a TD
- DraftKings Promo Code: Bet $5+ On Any NFL Pre-Game ML, Get $200 If Your Bet Wins
- Caesars Promo Code: Up To $1,250 Back On Your First Bet + 1000 Tier Credits + 1000 Reward Credits®
- PointsBet Promo Code: Get 4x $200 Second-Chance Bets For The NFL
Find all the latest Sportsbook Promo Codes and Bonuses for NFL Week 16, including sportsbooks live in your state.
NFL Week 16 big-game predictions
- Lions vs Panthers predictions
- Bills vs Bears predictions
- Seahawks vs Chiefs predictions
- Giants vs Vikings predictions
- Bengals vs Patriots predictions
- Eagles vs Cowboys predictions
- Raiders vs Steelers predictions
- Packers vs Dolphins predictions
- Broncos vs Rams predictions
- Buccaneers vs Cardinals predictions
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