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NFL Week 12 three-team mega parlay (+1140 odds): Can we make it two in a row after last week's 18/1 winner?

NFL Week 12 three-team mega parlay (+1140 odds): Can we make it two in a row after last week's 18/1 winner?

Andrew Ortenberg
Andrew OrtenbergAuthor
UpdatedSep 15, 2026
Reading time3 min

The 2021 NFL season has been thrilling so far, and we have another great slate coming up for Week 12. Why not celebrate the fun by going for a big payday? That’s right; we’re back with another mega parlay, NFL edition. I have had a ton of success with these mega parlays, and even hit one at 74/1 in Week 13 last year.

I also just hit it this past Sunday for Week 11 at +1762. We came up one last-second field goal short of cashing the Thanksgiving one at 17/1 as well. Why not do it once more? We’re going big and bold again, so let’s not waste any more time. But before we dive in, don’t forget to check out our picks for the side and total on every NFL game.

New York Giants ML (+160)

Carolina Panthers -2 (-110)

Minnesota Vikings (+150)

Parlay odds: +1140

Let’s break down each of the three legs one by one.

New York Giants ML (+160) over Philadelphia Eagles

To start this mega parlay off, I’m going with Daniel Jones and the Giants. The latest rendition of the Danny Dimes experience didn’t go too well on Monday Night Football, but that was a tough road game against the defending Super Bowl champions. This is a much softer matchup against an Eagles team I think is being overrated. Has Philly won three of its last four games? Yeah, sure, great.

Those three wins were against the Lions and rapidly spiraling Broncos and Saints teams. Now Jalen Hurts has to go on the road to face a Giants defense that has quietly played very well recently. In their three prior games before playing Tampa Bay, New York had allowed only 39 total points. The Giants completely shut down Patrick Mahomes during that span, and even last week in their loss to the Bucs only allowed Tom Brady to average 6.7 yards per attempt.

Be sure to check out our full game preview.

Carolina Panthers -2 (-110) over Miami Dolphins

Now for the only leg of our parlay that isn’t a money line ‘dog. Similar to the Eagles hype, people got a bit carried away with the praise for the Dolphins after their upset win over the Ravens. Miami’s other two wins in its recent resurgence? They came against the Texans (in Tyrod Taylor’s first start after a lengthy absence) and Jets. The Fins didn’t look too good while beating the Jets, which tells you everything you need to know.

Carolina is coming off a tough close loss to Washington, but Washington is just better than most people seem to realize. Cam Newton has given the Panthers a huge boost and their defense is playing very well. They should be able to hold Tua Tagovailoa in check. It also doesn’t hurt that the Panthers are 10-3 ATS on the road during the Matt Rhule era.

Be sure to check out our full game preview.

Minnesota Vikings (+150) over San Francisco 49ers

To wrap up this mega parlay and hopefully bring us home, we have the Vikings in the late slate. Minnesota is 5-5 but it should probably be more like 8-2. They Vikes have the potential to be elite on both sides of the ball, and have a really high ceiling. Just last week they beat the Packers, who had been looking like the best team in the NFC. I’m not ready to hop back on the 49ers bandwagon just because they pummeled the Jaguars last week.

This is still a team that got blown out at home by Colt McCoy just a few weeks ago. The 49ers have played well at home in a long time, and are just 1-8 straight up their last nine times playing in their own stadium. Kirk Cousins doesn’t get any credit, but he’s been one of the best quarterbacks in the NFL this year.

Be sure to check out our full game preview.

Pickswise is the home of free NFL Predictions  and NFL Odds. Check out the latest NFL Prop Bets and NFL Parlays as well as expert NFL Underdog Picks and NFL Computer Picks

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