NFL Week 5 Betting Guide: Picks, Predictions & Props for the NFL This Week
Welcome to the Pickswise NFL Week 5 betting guide! The 2025 campaign is well underway and it continued with the San Francisco 49ers pulling off a significant upset over the Los Angeles Rams on Thursday Night Football. Now we can focus on a 12-game Sunday slate. Our experts have done the hard work so you have everything you need to bet better and get the right results. This is your one-stop shop for everything you need to make the most of your NFL weekend. You can also read our great NFL predictions for every game on the Week 5 slate of the NFL regular season.
NFL Week 5 picks
- NFL picks for EVERY Week 5 game
- NFL best bets
- NFL parlays
NFL Week 5 expert betting picks and predictions
- Pickswise experts’ best bets — find out our top plays across Sunday’s card
- NFL Week 5 mega parlay — we cashed a +2512 parlay in Week 1!
- NFL Patriots vs Bills Same Game Parlay
NFL Week 5 prop bets
- Week 5 touchdown scorer best bets
- Sunday Night Football player props
- Sunday Night Football touchdown scorer best bets
NFL Week 5 predictions
- Broncos vs Eagles predictions
- Raiders vs Colts predictions
- Commanders vs Chargers predictions
- Giants vs Saints predictions
- Buccaneers vs Seahawks predictions
- Bills vs Patriots predictions
- Chiefs vs Jaguars predictions
