Below you will find our NFL week 2 picks against the spread and straight up for every game this week. Read our expert’s in-depth NFL week 2 predictions for the best wagers of the second week of the NFL. Head on over to our NFL parlays page to see our combined picks for week 2 or our NFL odds page to make sure you get the best price on your wager.
The home of our free NFL Picks and Predictions for week 2 of the 2021/22 NFL season.
Our expert NFL handicappers, research the entire NFL Week 2 schedule, leaving no stone unturned to bring you the best NFL expert picks across the week 2 slate.
We take a look through all of the week 2 NFL games, bring you the entire schedule, including the week 2 spreads, betting lines, and Moneyline favorites and our week 2 NFL picks and predictions will encompass all of these popular NFL Betting lines, alongside our match previews and analysis.
Thursday, Sept. 16
New York Giants at Washington Football Team, 8:20 p.m. ET (Thursday Night Football)
Sunday, Sept. 19
New Orleans Saints at Carolina Panthers, 1 p.m. ET
Cincinnati Bengals at Chicago Bears, 1 p.m. ET
Houston Texans at Cleveland Browns ET
Los Angeles Rams at Indianapolis Colts, 1 p.m. ET
Denver Broncos at Jacksonville Jaguars, 1 p.m. ET
Buffalo Bills at Miami Dolphins, 1 p.m. ET
New England Patriots at New York Jets, 1 p.m. ET
San Francisco 49ers at Philadelphia Eagles, 1 p.m. ET
Las Vegas Raiders at Pittsburgh Steelers, 1 p.m. ET
Minnesota Vikings at Arizona Cardinals, 4:05 p.m. ET
Atlanta Falcons at Tampa Bay Buccaneers, 4:05 p.m. ET
Dallas Cowboys at Los Angeles Chargers, 4:25 p.m. ET
Tennessee Titans at Seattle Seahawks, 4:25 p.m. ET
Kansas City Chiefs at Baltimore Ravens, 8:20 p.m. ET (Sunday Night Football)
Monday, Sept. 20
Detroit Lions at Green Bay Packers, 8:15 p.m. ET (Monday Night Football)
Our experts take a complete look at all of the NFL odds for Week 2. The balance between a confident NFL pick and good value odds is an important one, so taking a look at the Week 2 NFL odds is always important ahead of making your NFL Week 2 picks or wagers.
With many different NFL betting lines to focus on for any given match, we take a look at the main three, most popular markets in the NFL week 2 Money line odds, Spreads, and Totals.
The NFL Week 2 Odds will appear here once the Week 2 odds have been set and are available at the Top Online Sportsbooks
Check out the NFL Week 2 Spreads and Money Line favorites at all of the best online sportsbooks below.
Check out all of the NFL Week 2 Totals betting Lines from the top online sportsbooks below.
The start doesn’t get any easier for the Chiefs, with two of the AFC North contenders back-to-back to open the season. The Ravens similarly to the Browns and the Chiefs themselves will all be vying for the position of AFC Champion this season. Another thrilling early-season matchup here!