College Football Week 2 Betting: Odds, Picks & Best Bets for Saturday, September 12

It's Saturday, and you know what that means - college football day! After a wild Week 1 that saw big wins, major upsets, and huge controversy in Michigan, it's safe to say the new college football season started with a bang. And if that's a taste of what we're in for through the rest of the 2026 season, then there's a lot to be excited about.

With more than 60 CFB FBS games on the docket, there's tons to look forward to, and you can find out all of our college football picks and CFB predictions for the major matchups on Saturday, with 32 games covered. On top of that, we have our college football expert’s best bets of the day, along with our CFB parlays to help you bet better today across all of the NCAAF action. Let’s dive in!

College football Week 2 Best Bets

• CFB Week 2 best bets - our experts are 11-1 with their top college football picks since the season started! Let's keep that huge run going with Saturday's best plays

College football Week 2 Parlays

Get set for another huge Saturday slate in the 2026 CFB season with our experts' best college football parlays:

• College Football Week 2 Parlay - we've already cashed 2 parlays this season! Let's add another with this Saturday parlay at +1218 odds!
• Ohio State vs Texas Same Game Parlay - we hit our SMU vs FSU SGP on Monday night at +445 odds! Let's make it two in a row

College football Week 2 Player Props

• CFB Week 2 player props - check out our expert's three best player prop picks for Week 2's Saturday slate
• CFB Week 2 anytime touchdown scorer best bets - after going 3-0 on TD scorer picks last Saturday, let's run it back and add some more winners

College football Week 2 Picks

Check out our expert college football predictions for the biggest games in Week 2 below:

• Ohio State vs Texas prediction
• Oklahoma vs Michigan prediction
• Oregon vs Oklahoma State prediction
• Arizona State vs Texas A&M prediction
• Penn State vs Temple prediction
• Howard vs Indiana prediction
• Western Kentucky vs Georgia prediction
• Alabama vs Kentucky prediction
• Duke vs Illinois prediction
• Rice vs Notre Dame prediction
• Eastern Michigan vs Michigan State prediction
• Memphis vs Boise State prediction
• Texas Tech vs Oregon State prediction
• Iowa State vs Iowa prediction
• Arkansas vs Utah prediction
• Louisiana vs USC prediction