Chicago White Sox vs Seattle Mariners Prediction, Odds and Picks for Today, 05/18/26

The Chicago White Sox kick off a six-game West Coast road trip with a series opener against the Seattle Mariners on Monday. The White Sox are flying high after taking two of three games in an interleague series against the city rival Chicago Cubs. The Pale Hose outlasted the Cubbies 9-8 at Rate Field on Sunday as a slight underdog (+112) as the Over (9) easily cashed. The total has gone high in six in a row, and eight of the past 10 games, in case you’re looking for a nice same-game parlay (SGP) opportunity. However, we’re really focusing more on the side here.

White Sox LHP Noah Schultz (2-2, 4.91 ERA, 1.36 WHIP) takes the ball for the visitors, while Mariners RHP Bryan Woo (3-2, 3.91 ERA, 1.00 WHIP) works for the home side. He has been much better at home, going 2-0 with a 3.60 ERA and 0.80 WHIP across 25 IP in four starts at T-Mobile Park. Teams are hitting just .180 against him in Seattle, too, as he has managed to throw a blanket on many visiting offenses this season. Let’s back the Mariners to get the job done, even though the ChiSox have been pretty hot lately, and they’re playing with a lot of confidence.

Mariners ML (-180) at time of publishing. Playable at that number.