Cleveland Guardians vs Philadelphia Phillies Prediction, Odds and Picks for Today, 05/23/26

The Guardians extended their winning streak to 7 games yesterday after a 1-0 shutout over the Phillies. Not only was it their 7th win in a row, but it was their 10th in their last 11 and 13th in their last 15. Needless to say, Cleveland is running hot right now. Philadelphia was in a similar boat earlier this week, but the Phillies have now lost 3 in a row after a stretch of 8 wins in 9 games.

Saturday’s pitching matchup pits Cleveland’s Slade Cecconi against Philadelphia’s Zack Wheeler. On the surface, Cecconi’s numbers are awful with a 3-4 record, 5.16 ERA and 1.49 WHIP. At one point, the Guardians were even 0-6 SU in his starts. However, they have won his last 4, while he has surrendered just 4 earned runs across his last 3 starts. Meanwhile, Wheeler is off and running this season after a late start. Through 5 appearances, Wheeler is 3-0 with a 1.99 ERA and a 0.88 WHIP. The Phillies are a perfect 5-0 in his starts. 

Cleveland may be running hot, but the streak figures to ends here. The Guardians are one of the worst teams in the league when it comes to batting average and slugging percentage against righties, and Wheeler is about as elite of a right-hander as it gets. Not to mention, this roster has just 22 combined career at bats against Wheeler outside of Rhys Hoskins, who has 24 from his days playing in the NL. In that small sample size, the team’s batting average against Wheeler is just .217, while its on-base percentage is below .300. Phillies get right on Saturday.

Guardians vs Phillies prediction: Philadelphia Phillies ML (-190) at the time of publishing. Playable to -200. 

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