Houston Astros vs Chicago Cubs Prediction, Odds and Picks for Today, 05/23/26

Game 2 of the three-game series between the Houston Astros and Chicago Cubs will be played on Saturday afternoon at Wrigley Field. The Astros took the win in Game 1 by a score of 4-2. With the loss, the Cubs are now on a six-game losing streak, and 2-8 in their last 10 games. Their offense has been struggling big time recently, only scoring more than three runs in a game once in their last six games. They will be sending Colin Rea to the mound on Saturday who has not been great this season. Rea has a 4.98 ERA in 47.0 innings. He has given up nine earned runs in his last 9.0 innings pitched.

The few Astros batters that have faced Rea have solid numbers against him. Look for them to put up a few runs with him on the mound. The Astros will be countering with Kai-Wei Teng, who pitched five scoreless innings in his last outing and lowered his ERA to 2.61 in 31.0 innings on the season. There is some value on the Astros here as road underdogs. Give me the Astros in this one.

Astros vs. Cubs prediction: Astros ML (+125) available at time of publishing. Playable to +115.