Pittsburgh Pirates vs St. Louis Cardinals Prediction, Odds and Picks for Today, 05/20/26

Game 2 of this series between the Pittsburgh Pirates and St. Louis Cardinals will be played on Wednesday evening. The Cardinals won Game 1 by a score of 9-6. The win improved their record to 6-4 in their last 10 games, and an impressive 28-19 overall on the season. With the loss, the Pirates are now riding a four-game losing streak and they are 3-7 in their last 10. The Cardinals will be sending Michael McGreevy to the mound for Game 2 and he has been lights-out in his last four starts. He pitched 6.0 innings in all four of the starts and has only given up two earned runs over that stretch. For a struggling Pirates team, this is not exactly what they want to see. The Cardinals are 6-1 against teams within their division, I like their chances to improve that record on Wednesday.

The Pirates offense has been brutal recently. They were shutout in two of their last three games, and things do not get any easier going up against McGreevy. Give me the Cardinals in this one.

Pirates vs. Cardinals prediction: Cardinals ML (-120) available at time of publishing. Playable to -130.