San Diego Padres vs Seattle Mariners Prediction, Odds and Picks for Today, 05/16/26

Game 2 of the three-game weekend series between the San Diego Padres and Seattle Mariners will be going Saturday night in Seattle. The Padres won a low-scoring Game 1, 2-0. The Mariners offense has been slow to begin the season; they are ranked 17^th in the MLB averaging 4.2 runs per game. They will have a good chance to get the bats going and bounce back from being shutout on Friday as they face off against Walker Buehler, who is getting the start for the Padres. Buehler has been shaky this season; he has a 5.20 ERA in 36.1 innings pitched. Look for the Mariners to score some runs on him.

Despite their 26-18 record, the Padres offense has not been good. They average only 4.1 runs per game, which is ranked 22^nd in the MLB. They have not scored more than four runs in a single game in their last eight games. They are going up against Logan Gilbert, who is coming off an impressive start where he pitched 6.0 innings, gave up one hit and struck out nine batters, without giving up a run. This will be a tough game for the cold bats of the Padres. As a team, the Mariners are allowing the sixth-fewest runs per game at 3.8. Give me the Mariners in this one.

Padres vs. Mariners prediction: Mariners ML (-165) available at time of publishing. Playable to -170.