The Athletics vs Los Angeles Angels Prediction, Odds and Picks for Today, 05/21/26

The Athletics picked up a 6-5 victory on Wednesday in the 3rd game of a 4-game set. Two of the first 3 games have been decided by a single run, with the A’s winning 14-6 on Tuesday night. Following last night’s win, the A’s have won consecutive games for the first time since a 3-game streak May 7-9. Prior to Tuesday, the A’s were a dismal 2-6 in their previous 8 outings from May 10-18. They turn to RHP Luis Severino (2-5, 4.45 ERA, 1.57 WHIP) for Thursday’s finale. The veteran has had difficulty keeping the ball in the yard, but most of that difficulty is at home. On the road, he has a respectable 3.56 ERA in 30.1 IP across 6 starts, allowing just 1 of his 7 total homers. Still, he has walked 20 batters, and teams are hitting .263 against him on the road — which is why he is 1-3.

For the Angels, they turn to RHP Jose Soriano (6-3, 2.41 ERA, 1.07 WHIP), who had been humming along with a sub-2.00 ERA until getting tattooed by the visiting LA Dodgers on Saturday — giving up 6 runs in 5.2 innings with 6 walks and just 1 hit allowed. He was all over the place, and he has come apart a bit in May, going 1-2 with a 6.35 ERA. As such, we’re giving the A’s the slight edge here at even money.

Athletics vs Angels prediction: A’s (+100) at time of publishing. Playable to -110.

You can bet on our Athletics vs Angels pick with BetMGM, where right now new users can activate your new BetMGM account ⚡ and receive $150 in bonus bets INSTANTLY if your first $10+ wager is a winner!