Washington Nationals vs Cleveland Guardians Prediction, Odds and Picks for Today, 05/26/26

The Washington Nationals drew first blood in this interleague series on Monday night, pounding the homestanding Cleveland Guardians 10-2, as Tanner Bibee continues to struggle for the home side. The Guardians look to bounce back behind LHP Joey Cantillo, who has been dealing this season, particularly at home. The southpaw is 2-0 with a 3.04 ERA across 26 2/3 IP in 5 home starts, allowing just 2 homers with 12 walks and a high strikeout rate, posting 29 Ks. On the flip side, the Nationals counter with RHP Cade Cavalli, who is 2-3 with a 3.86 ERA and 1.43 WHIP in 11 starts. On the road, he is a little more giving with a 4.37 ERA, so consider that in same-game parlays, if you so choose.

However, we’re concentrating on the Under. The Over cashed in Monday’s series opener, with the Nats getting to double digits, but the bottom should fall out on their offense against the Hawaiian hurler. The Under has cashed in two of Cavalli’s past three starts, while the Under is 6-1 in the past seven games for the Guardians. In fact, that made the Over on Monday all the more stunning. Let’s go low on the total, in what should be a surprisingly well-pitched game.

Nationals vs Guardians prediction: Under 7.5 (-115) at time of publishing. Playable to -120.

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