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College Football Week 11 opening lines, odds and best bet: Colorado poised for another road victory and cover

College Football Week 11 opening lines, odds and best bet: Colorado poised for another road victory and cover

Sam Avellone
Sam AvelloneAuthor
UpdatedAug 21, 2026
Reading time4 min

College football Week 10 is in the books, which means our focus turns to Week 11. Midweek “MACtion” will kick things off on Tuesday night, and there will be games every night leading up to Saturday’s full slate. Army did not come through for us last week, so we are now 6-3 on these opening line best bets. However, this week is as good as any to get back into the win column. 

Below you will find the current lines and odds for all of Week 11’s biggest college football matchups. Like every week, I will wrap things up with my favorite play of the bunch. Don’t forget to check out our college football picks and NCAAF predictions for all of this week’s most impactful games.

College football Week 11 opening lines and odds

Odds courtesy of Bet365 and available at the time of publishing on Sunday night.

  • Bowling Green -12 (-110) @ Central Michigan – Tuesday, November 5th
  • Miami (OH) -11.5 (-110) @ Ball State – Tuesday, November 5th
  • Northern Illinois -1.5 (-110) @ Western Michigan – Wednesday, November 6th
  • Ohio -18.5 (-110) @ Kent State – Wednesday, November 6th
  • Coastal Carolina -1 (-110) vs Appalachian State – Thursday, November 7th
  • Iowa -6.5 (-110) @ UCLA – Friday, November 8th
  • NC State -3 (-110) vs Duke – Saturday, November 9th
  • Texas -21.5 (-110) vs Florida – Saturday, November 9th
  • Iowa State -3 (-110) @ Kansas – Saturday, November 9th
  • Miami -11.5 (-110) @ Georgia Tech – Saturday, November 9th
  • Boston College -1.5 (-110) vs Syracuse – Saturday, November 9th
  • Texas State -7 (-110) @ UL Monroe – Saturday, November 9th
  • Pittsburgh -7 (-110) vs Virginia – Saturday, November 9th
  • Cincinnati -4 (-110) vs West Virginia – Saturday, November 9th
  • Arizona State -4 (-110) vs UCF – Saturday, November 9th
  • Army -5.5 (-110) @ North Texas – Saturday, November 9th
  • Colorado -3 (-110) @ Texas Tech – Saturday, November 9th
  • Georgia -2.5 (-110) @ Ole Miss – Saturday, November 9th
  • Indiana -14 (-110) vs Michigan – Saturday, November 9th
  • Minnesota -6 (-110) @ Rutgers – Saturday, November 9th
  • Missouri -2.5 (-110) vs Oklahoma – Saturday, November 9th
  • TCU -11 (-110) vs Oklahoma State – Saturday, November 9th
  • Penn State -13.5 (-110) vs Washington – Saturday, November 9th
  • South Carolina -3.5 (-110) @ Vanderbilt – Saturday, November 9th
  • Tennessee -24 (-110) vs Mississippi State – Saturday, November 9th
  • Oregon -24.5 (-110) vs Maryland – Saturday, November 9th
  • Alabama -3 (-110) @ LSU – Saturday, November 9th
  • Notre Dame -25.5 (-110) vs Florida State – Saturday, November 9th
  • Clemson -6.5 (-110) @ Virginia Tech – Saturday, November 9th
  • BYU -4.5 (-110) @ Utah – Saturday, November 9th

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NCAAF Week 11 early best bet: Colorado Buffaloes -3 over Texas Tech Red Raiders (-110)

The Red Raiders return home to Lubbock following 2 consecutive highly contested road games at TCU and Iowa State. Texas Tech lost to the Horned Frogs 35-34, then followed it up with a 23-22 win over the Cyclones in Week 10. With the win, the Red Raiders are 6-3 overall and tied for 3rd in the Big 12 at 4-2. They are 1 game behind the Colorado Buffaloes in the conference standings, whom they welcome to Lubbock this week. Unfortunately for the Raiders, the Buffaloes come into this game after an idle week. With the extra rest, Colorado should be set up for success in this matchup. 

Shedeur Sanders and the Colorado passing attack has been highly efficient in recent weeks. The Buffaloes are 4th in pass success rate and 15th in pass PPA since Week 6, with a top-20 mark in havoc allowed. Texas Tech will counter with a defense that is outside the top 80 in opposing pass success rate and pass PPA in that time, as well as outside the top 110 in havoc generated. The Red Raiders may find it difficult to get stops against this rested Colorado offense, which has not had issues scoring on the road outside of the Week 2 loss at Nebraska. I like the situational spot here for Colorado, in addition to the on-field matchup for its passing attack against the Texas Tech secondary. 

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