Four-pick cross-sport parlay for Sunday (+1197 odds): NFL preseason and MLB picks

Jimmy Garoppolo Playing Against Vikings
Photo of Matthew Lowrimore

Matthew Lowrimore

NFL· 3 weeks ago

Show Bio

Matthew has been with Pickswise for over a year now, covering a wide variety of sports. His main passion is college football and that is the sport he has covered the most. Matthew uses a variety of methods to handicap games, including stats, trends, injuries, and situational factors. His goal is to consistently give out winners and will do everything he can to make his readers money.

We have put together a 4-pick cross-sport parlay that will take you right through Sunday night, including action from the NFL preseason and MLB.

Three picks are taken from the MLB with 1 coming from the NFL preseason. A winning ticket gives us a nice payout with odds at +1197 with BetMGM; that’s more than 11/1! Let’s break down each of these plays. Remember to gamble responsibly.

MLB pick: Miami Marlins vs Cincinnati Reds ML (-135), 1:10pm ET

Marlins righty Sandy Alcantara was roughed up in Colorado a couple of weeks ago, with 10 runs allowed in only 3.0 innings. Reds rookie Vlad Gutierrez has not faded as the season has ramped up. He has given up 1 or 2 runs in 5 straight starts with the Reds winning 4 of them. I like that the rookie seems to be getting better as the season has progressed. Cincinnati is by far the better form team and Gutierrez helps them close the weekend with a win. Take Cincinnati.

Be sure to check out our full game preview for this matchup. You can also read the rest of our MLB picks and predictions, as well as our prop betsparlays, and MLB Best Bets.

MLB pick: Seattle Mariners vs Houston Astros -1.5 (+100), 2:20pm ET

Tyler Anderson will be making his fifth appearance for the Mariners this season, and while he has pitched well with Seattle, he hasn’t exactly faced intimidating opponents. Anderson is posting a respectable 2.91 ERA in 21.2 innings with the Mariners, but he faced the last-place Rangers in 3 of those 4 starts.  

Houston entered Saturday with the highest batting average (.273) and OPS (.778) against left-handers in the American League. In addition, the Astros managed 7 hits and 7 runs in just 2.2 innings against the left-handed Yusei Kikuchi in the first game of this series.  The Astros are typically tough to face at home, so Anderson could have his hands full in this one. Houston has dominated the first two games of this series, and they seem to be in a favorable position to keep it going on Sunday. Back the Astros -1.5.

Be sure to check out our full game preview for this matchup. You can also read the rest of our MLB picks and predictions, as well as our prop betsparlays, and MLB Best Bets.

MLB pick: Kansas City Royals ML (-105) vs Chicago Cubs, 2:20pm ET

Chicago has been awful since the all-star break as the Cubs have now lost 12 straight games at home. The lineup ranks among the bottom five teams in hits,  batting average, and went 6 full innings last night without a single hit against Kris Bubic. Chicago has 2 victories over the past 2 weeks, so take the Royals to earn the road sweep at Wrigley Field today.

Be sure to check out our full game preview for this matchup. You can also read the rest of our MLB picks and predictions, as well as our prop betsparlays, and MLB Best Bets.

NFL preseason pick: San Francisco 49ers vs Los Angeles Chargers – Under 34 points (-110), 7:30pm ET

Even with the 49ers playing Jimmy Garoppolo and Trey Lance, they are pretty unlikely to be in any type of hurry. They were the 2nd-slowest team in the NFL in neutral-situation pace last season and not much has changed in the early going of this preseason. On the other side of the ball, Chase Daniel and Easton Stick really don’t move the dial. They were running the most vanilla of vanilla offenses last week. Why would that change this week?

Even if they do mix things up a little, the 49ers just held the Chiefs to 19 points last week. Kansas City was pretty aggressive for a preseason game and it took a late touchdown run for them to even get to 19. It’s hard to see much of a path over this low number.

Be sure to check out our full game preview for San Francisco 49ers vs Los Angeles Chargers.

Pickswise is the home of free MLB picks and predictions. Make sure to check out our MLB parlays and MLB prop bets tabs for more expert picks.

Virginia Bonuses

See All
DraftKings

$200

Bet $1 On Any NFL Football Game & Get $200 In Free Bets Instantly!

Register for a new DraftKings Sportsbook account

Bet $1 on any Pro Football game

Instantly get $200 in free bets

BetMGM

$200

Bet $10, Get $200 If Your Team Scores A Touchdown!

Register for a new BetMGM account & deposit $20+

Bet $10 on your team to win Money Line

Win $200 in free bets if your team scores a touchdown

21+. Terms & conditions apply.

FanDuel Sportsbook

$150

Bet $5, Win $150 if the Chiefs or Ravens win!

Make a new account with FanDuel Sportsbook

Bet $5 on either the Chiefs or Ravens to win their Week 2 matchup

If your team wins, you win $150 cash!

New players only. Max bet $5. Must be 21+ to play. Full terms available at FanDuel Sportsbook.

PointsBet

$200

Bet $20, Get $200 If Your Team Scores A Touchdown!

Register for a new PointsBet account & deposit $20+

Bet $20 on your team to win Money Line (NFL or NCAAF)

Win $200 in free bets if your team scores a touchdown

Caesars Sportsbook

$5,000

Get a $5,000 Risk Free Bet + a free NFL Jersey!

Register for a new Caesars Sportsbook account & make a deposit

Place your first bet up to $5,000 risk-free!

Get refunded up if you lose up to $5,000 + a free NFL Jersey

21+. Terms & conditions apply.

BetRivers

$250

Get a $250 Deposit Bonus!

Sign up for a new BetRivers account using promo code PICKSWISE

Make a deposit & get it doubled up to $250 total

To get a $100 bonus, deposit $100

Must be 21+. Play in IA Only. Gambling Problem? Call 1-800-BETS OFF

BetMGM

$1,000

Get a $1,000 Risk Free Bet!

Register for a new BetMGM & deposit

Place your first bet up to $1,000 risk-free!

Get refunded up if you lose up to $1,000

21+. Terms & conditions apply.

FanDuel Sportsbook

$1,000

Get a $1,000 Risk Free Bet!

Register for a new FanDuel Sportsbook account & deposit

Place your first bet up to $1,000 risk-free!

Get refunded up if you lose up to $1,000

21+. Terms & conditions apply.

DraftKings

$1,000

Get a $1,000 Deposit Bonus!

Register for a new DraftKings Sportsbook account & deposit

DraftKings will match 20% of your deposit up to $1,000 total

To get a $100 bonus, deposit $500

21+. Terms & conditions apply.

Monkey Knife Fight

$100

Claim 100% Instant Deposit Match up to $100!

Register for a Monkey Knife Fight account & deposit using promo code PICKSWISE100

Monkey Knife Fight will match your first deposit up to $100

Deposit $100 and you'll get $100 bonus + a free $5 game

18+. Terms and conditions apply. You must live in one of the states where real money DFS is legal.

TVG

$300

Get a $300 Risk-Free Bet with TVG Racebook!

Register for a new TVG account and make a deposit

Place your first single horse win-type bet up to $300

If your horse doesn't win you'll get a refund up to $300

21+. T&C's apply. Please gamble responsibly.

BetAmerica Racing

$200

$200 Sign Up Bonus!

Fast, reliable and fast payouts - you'll have your money in 72 hours, if not sooner!

Proud history of providing safe, secure, and fun betting to American patrons

BetAmerica is owned by the iconic Churchill Downs Incorporated, home of 150 years of wagering history and the world-famous Kentucky Derby

Players who sign up using ‘BET200’ code will get a $200 sign up bonus. Offer valid for 7 days after registering on BetAmerica Racing product only. 21+. T&C's apply. Please gamble responsibly.

TwinSpires

$200

Get a $200 Sign Up Bonus with TwinSpires Racebook!

Register for a new Twinspires account using offer code BET200

Make a deposit and start wagering on horse racing

Earn $100 in bonus cash for every $400 wagered!

21+. T&C's apply. Please gamble responsibly.