MLB Saturday mega parlay (+1053 odds): Let's make it 2 wins in 3 days!

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Caleb Wilfinger


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Deputy Editor for Pickswise with years of experience handicapping and giving out winning picks. Lover of all US sports and Southampton FC. For Caleb Wilfinger media enquiries, please email

It’s another jam-packed weekend in the MLB, and we have another loaded slate on Saturday with a number of compelling matchups. And what better way to celebrate a full slate of baseball than by going for a big payday? That’s right, we’re back with another mega parlay with a payout of over 10/1 odds at DraftKings Sportsbook. I just cashed my MLB mega parlay on Thursday at +943 odds — let’s make it 2 wins in 3 days!

Before we dive in, don’t forget to check out our free picks on the side and total for every MLB game today. Let’s get into our mega parlay for Saturday. 

San Diego Padres -2.5 alternate run line (+150)

Miami Marlins ML (+105)

New York Yankees -1.5 (+125)

Parlay odds: +1053

Let’s break down each of the legs one by one.

Odds available at DraftKings Sportsbook at time of publishing. 

San Diego Padres -2.5 (+150) alternate run line over Pittsburgh Pirates

To start off this mega parlay, we have the San Diego Padres on an alternate run line. While betting on the Padres has been profitable this season, this inclusion is more of a fade of the Pittsburgh Pirates. While they are more competitive than in recent years, the Pirates are once again among the worst teams in baseball. Their pitching is still severely lacking, as Pittsburgh ranks 26th in team ERA, a clear contrast to the Padres’ top-10 pitching staff. Things won’t get any easier for the Pirates with J.T. Brubaker getting the start on Saturday, as the right-hander has been wildly inconsistent to this point. Brubaker will be opposed by Joe Musgrove, who is quietly putting together a career-best season. With Musgrove holding a 1.90 ERA and 52 strikeouts, runs will be hard to come buy for Pittsburgh.

If Manny Machado and company tag Brubaker for a couple of early runs, Musgrove should settle in and cruise against the Pirates mediocre offense. Back the Padres to win comfortably.

Check out our full game preview for Pittsburgh Pirates vs San Diego Padres

Miami Marlins ML (+105) over Atlanta Braves

The second leg of this parlay has us backing the Miami Marlins on the money line. The Marlins are having trouble winning games, but they usually play teams very close. This is due in large part to the pitching the Fish have at their disposal, including Saturday’s starter Sandy Alcantara. Alcantara has been excellent in 2022, and is coming off a complete game performance against Atlanta in his last start. With only 14 runs allowed and a 2.11 ERA in 60 innings pitched, the clear edge on the mound lies with the Marlins.

While Miami has an ace on the hill, the Atlanta Braves are sending out Tucker Davison — who has allowed 10 runs in his first 10.0 innings of work in 2022. Davidson clearly has promise, but he might not be ready to be a consistent starter in the majors. Back the Marlins to even the series in Atlanta.

Check out our full game preview for Miami Marlins vs Atlanta Braves

New York Yankees -1.5 run line (+125) over Tampa Bay Rays

To finish off this mega parlay, we have the New York Yankees on the run line. This series features the top 2 teams in the AL East, but there is a clear gap between these sides. Even without a few key pieces on offense and in the bullpen, the Yankees have coasted through the opening 2 games of the series. The Tampa Bay Rays are a good team, but one that is missing that extra quality to put them over the top against the AL favorites. Plus, the Yankees will turn to ace Gerrit Cole, who will be looking to rebound after an uneven start his last time out.

Cole has historically pitched well at Tropicana Field and New York has won 6 of Cole’s last 7 starts. As long as the Bronx Bombers pick up a few runs off an inconsistent Corey Kluber, Cole should be able to pitch comfortably. And while it’s sustained a few setbacks, the Yankees’ bullpen is still very capable of protecting a multi-run lead. Back New York to win this important series on Saturday.

Check out our full game preview for New York Yankees vs Tampa Bay Rays

Pickswise is the home of free MLB Picks. Check out the latest MLB Prop Bets and MLB Parlays as well as our MLB Best Bets from the experts.

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