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MNF NFL Betting Guide: Lions vs 49ers picks, expert predictions, odds & best bets

MNF NFL Betting Guide: Lions vs 49ers picks, expert predictions, odds & best bets

Andrew Wilsher
Andrew WilsherAuthor
UpdatedSep 15, 2026
Reading time2 min

NFL Week 17 concludes with the Detroit Lions taking on the San Francisco 49ers on Monday Night Football. The Lions are locked in a vicious battle with divisional rival Minnesota after the Vikings beat the Packers on Sunday, and will be highly motivated to keep winning here to stay in the driver’s seat for the #1 seed while also getting revenge on the 49ers for their defeat in the NFC Championship game. As for San Francisco, they have been eliminated from playoff contention but will look to end the season on a high in their final home game of the season.

Lions vs 49ers kicks off at 8:15 pm ET live on ABC and ESPN, and here at Pickswise, we have everything you need to bet better on this MNF matchup, including NFL picks on the side and total, expert NFL player prop bets from props betting experts JutPicks and Andrew Wilsher, as well as a Lions vs 49ers Same Game Parlay at +632 odds! We’ve been on a roll with our SGPs lately, so here’s hoping we can add another winner. Let’s get into our MNF picks and expert Lions vs 49ers predictions.

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NFL MNF Picks & Lions vs 49ers Predictions

  • Detroit Lions vs San Francisco 49ers predictions — get picks on the side and total from our red-hot NFL expert!

Lions vs 49ers best player prop bets

Detroit Lions vs San Francisco 49ers Same Game Parlay

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NFL Week 18 Predictions

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