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USA vs Panama CONCACAF Gold Cup predictions, picks, odds & spreads: Tricky test for USMNT

USA vs Panama CONCACAF Gold Cup predictions, picks, odds & spreads: Tricky test for USMNT

Dan Childs
Dan ChildsAuthor
UpdatedSep 15, 2026
Reading time3 min

The CONCACAF Gold Cup has reached the semifinal stage, and the United States’ victory over Canada in the quarterfinals means that only 2 of the tournament’s big 3 teams remain in contention. Mexico could lie in wait in Sunday’s final at SoFi Stadium, but first the USMNT must tackle a Panama team who should be growing in confidence.

The game kicks off at 7:30 pm ET on FS1 at Snapdragon Stadium in San Diego and our expert has picks, predictions and a best bet, as well as the latest odds for this matchup. You can also check out the rest of our soccer picks for the Gold Cup action.

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USA vs Panama CONCACAF Gold Cup odds & betting lines

Odds available at DraftKings Sportsbook at time of publishing.

Money line odds: USA -165, Panama +500, Tie +300
Over/under 2.5 goals: Over 2.5 +115, Under 2.5 -145

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USA vs Panama expert picks for Wednesday’s CONCACAF Gold Cup semifinal

USA vs Panama best bet: Panama or Tie double chance (+130, DraftKings)

Seven-times CONCACAF Gold Cup champions USA squeezed through to the semifinals with a penalty shootout success over Canada on Sunday, but they have not been entirely convincing in this tournament and are far from certain to defeat Panama inside 90 minutes in Wednesday’s first semifinal at the Snapdragon Stadium in San Diego. The Stars & Stripes are attempting to win the tournament without several first-choice players and their limitations were exposed from the start of the group stage when they needed an 88th-minute Brandon Vazquez goal to earn a 1-1 against Jamaica. The USA were equally unconvincing in the quarterfinal match against Canada, who led 2-1 in extra-time until Scott Kennedy’s dramatic 114th-minute own goal led to the USA winning on penalty kicks.

Panama won Group C and continued its impressive progress with a 4-0 quarterfinal success against Qatar. Taking the Panama or Tie double chance option cashes if the underdogs win the game or even just force the USA to go into extra-time again. Panama has not reached the final of this competition since 2013 but should prove to be no pushover.

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