Wise n' Shine: MLB picks, college football predictions and NFL odds for Friday, September 22

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Phil Agius


Show Bio

I've been writing about the NFL and a host of other sports for the UK's top daily betting paper the Racing Post for more than 20 years. An incurable Browns fan (1-31 survivor), I also specialise in all kinds of motorsport betting including F1, MotoGP, IndyCar and NASCAR. For Phil Agius media enquiries, please email contact@pickswise.com.

Good morning, Pickswise Nation, and welcome to another fantastic Friday of sports. We have a busy MLB slate to enjoy today, plus college football action, so let’s get straight to making your next bet better.

About Last Night

2-0 night for Pickswise on TNF!
The San Francisco 49ers moved to 3-0 with a comfortable 30-12 home win over the New York Giants on Thursday Night Football and it was a 2-0 night for Pickswise too as we cashed our picks of 49ers -10 and under 44.5, taking our record to 6-1-1 against the spread in primetime NFL games this season! The 49ers are +650 favorites for the Super Bowl at DraftKings Sportsbook now. FanDuel has them at the same price but behind the Chiefs (+550).

8-3 day of MLB picks
It wasn’t the biggest slate of games on Thursday, but our cappers certainly made it work for them with an 8-3 overall record to take our performance over the past 4 days to 35-15! On top of that, we cashed our MLB parlay for the 2nd day in a row at +408 odds. Our insane MLB props run continued with our 10th straight winning pick and making it 23 wins in our last 28 prop plays!

Now you can bet any of our sports predictions at FanDuel Sportsbook, which has a great new-customer offer to take advantage of. If you sign up for FanDuel right now, you can bet $5 and receive $200 in bonus bets! Click here to join FanDuel right now and learn more.

Today’s Slate

15 MLB games on Friday
We have a full 15-game MLB slate today, with Apple TV+ showing Mets vs Phillies at 7:05 pm ET and Giants vs Dodgers at 10:10 pm ET. Read all of today’s MLB predictions.

Friday night lights are on
The Friday night CFB schedule provides a gentle warm-up for the madness of Saturday, and tonight it includes Wisconsin vs Purdue on FS1 at 7:00 pm ET and NC State vs Virginia on ESPN at 7:30 pm ET. Check out all our college football picks.

Best Bet of the Day

MLB: Arizona Diamondbacks ML over New York Yankees (+108)
7:05 pm ET

Arizona heads to the Bronx on Friday night. The Yankees are out of the playoffs and just running out the clock at this point. The Diamondbacks, on the other hand, have climbed up into the wild-card standings and look a great bet at plus-money. They have rookie Brandon Pfaadt on the mound, but he did spin 5.1 innings of scoreless baseball against the Cubs last time out. Luke Weaver going for the Yankees and he has bounced around from team to team because he isn’t effective any more. If Pfaadt can hold his own for a few innings, Arizona should be able to control this one. Read our full Diamondbacks vs Yankees predictions.

You can bet on today’s MLB games over at DraftKings Sportsbook, which has a great sign-up offer where you can bet $5 and get $200 in bonus bets instantly! Click here to take advantage and claim your bonus bets right now.


Today’s MLB mega parlay is available right now, along with our college football expert’s NCAAF Week 4 Best Bets and Week 4 CFB mega parlay and underdog picks, plus our NFL Week 3 prop picks and NFL Power Rankings.

Our UFC Fight Night 228 best bets and UFC four-fight parlay for tomorrow’s big fights are available and we also have soccer picks for tomorrow’s EPL action. Read all of our great sports analysis as it arrives throughout the day on the Analysis tab.

Stat of the Day

The Cubs have lost 7 of their last 8 games, and 10 of their last 13.

Quote of the Day

“I got you 7! No more need to be said!”

Cowboys defensive star Micah Parsons reassured cornerback Trevon Diggs that he will take care of business while Diggs recovers from a season-ending knee injury.

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