NFL Week 1 Sunday Betting Guide: Picks, Odds & Predictions

Sundays in 2026 will never be the same again, because the NFL is BACK! NFL Week 1 is already underway after the Seahawks edged the Patriots and the 49ers crushed the Rams, and now we look ahead to the mega 13-game slate on Sunday, September 13. With every team looking to start on the right foot and tons of red-hot matchups, our Pickswise experts have combed through it all with our expert NFL picks and NFL predictions for all 16 Week 1 games and every matchup throughout the entire season! In addition, we have our NFL best bets and NFL parlays to sink your teeth into. Let's dive in!

NFL Week 1 Best Bets

• NFL Week 1 best bets - get our four top picks from each of our NFL handicappers

NFL Week 1 Parlays

Go big in Week 1 with our experts' best NFL parlays for Sunday's action:

• NFL Week 1 Parlay - we finished up +23.8 units on our parlays last season! Let's make a winning start with our five-legger for Week 1
• Cowboys vs Giants SNF Same Game Parlay - celebrate the return of SNF in style and go for the mega payday with our expert's Cowboys vs Giants SGP!

NFL Week 1 Player Props

• Best NFL Week 1 player props - after cashing a winner in Patriots vs Seahawks, JutPicks is back with his three top props for Sunday's slate
• NFL Week 1 anytime touchdown scorer best bets - our TD scorer expert already went 3-0 on his CFB Week 1 plays, can he do the same for NFL Week 1?
• Cowboys vs Giants SNF Player Props - target these two plus-money plays for Sunday Night Football, including a prop at +381 odds!
• Cowboys vs Giants TD scorer best bets - we've already nailed winners on JSN at +130 and Deebo at +350 this week, can we add some more?

NFL Week 1 Picks

Check out our expert NFL predictions for every Week 1 matchup below:

• Bears vs Panthers prediction
• Browns vs Jaguars prediction
• Buccaneers vs Bengals prediction
• Falcons vs Steelers prediction
• Saints vs Lions prediction
• Bills vs Texans prediction
• Ravens vs Colts prediction
• Jets vs Titans prediction
• Packers vs Vikings prediction
• Commanders vs Eagles prediction
• Cardinals vs Chargers prediction
• Dolphins vs Raiders prediction
• Cowboys vs Giants SNF prediction
• Broncos vs Chiefs MNF prediction