NFL Week 6 Picks and Predictions

Below you will find our NFL week 6 picks against the spread and straight up for every game this week. Read our expert’s in-depth NFL week 6 predictions for the best wagers of the sixth week of the NFL. Head on over to our NFL parlays page to see our combined picks for week 6 or our NFL odds page to make sure you get the best price on your wager.

The home of our free NFL Picks and Predictions for week 6 of the 2022/23 NFL season.

Our expert NFL handicappers research the entire NFL Week 6 schedule, leaving no stone unturned to bring you the best NFL expert picks across the week 6 slate.

We take a look through all of the week 6 NFL games, bring you the entire schedule, including the week 6 spreads, betting lines, and money line favorites and our week 6 NFL picks and predictions will encompass all of these popular NFL Betting lines, alongside our match previews and analysis.

NFL Week 6 Schedule – NFL Games Week 6

Thursday, Oct. 13

Washington Commanders at Chicago Bears, 8:15 p.m. (Thursday Night Football)

Sunday, Oct. 16

San Francisco 49ers at Atlanta Falcons, 1 p.m.
New England Patriots at Cleveland Browns, 1 p.m.
New York Jets at Green Bay Packers, 1 p.m.
Jacksonville Jaguars at Indianapolis Colts, 1 p.m.
Minnesota Vikings at Miami Dolphins, 1 p.m.
Cincinnati Bengals at New Orleans Saints, 1 p.m.
Baltimore Ravens New York Giants, 1 p.m.
Tampa Bay Buccaneers at Pittsburgh Steelers, 1 p.m.
Carolina Panthers at Los Angeles Rams, 4:05 p.m.
Arizona Cardinals at Seattle Seahawks, 4:05 p.m.
Buffalo Bills at Kansas City Chiefs, 4:25 p.m.
Dallas Cowboys at Philadelphia Eagles, 8:20 p.m. (Sunday Night Football)

Monday, Oct. 17

Denver Broncos at Los Angeles Chargers, 8:15 p.m. (Monday Night Football)

Week 6 Byes

Detroit Lions, Houston Texans, Las Vegas Raiders, Tennessee Titans

NFL Odds Week 6

With many different NFL betting sites available, it’s important to shop the odds and lines each game week. Check out the best NFL Week 6 odds from the Top Online Sportsbooks below. You can find all of the NFL week 6 Money line odds, Week 6 NFL Spreads, and Week 6 NFL Total’s.

NFL Week 6 Spreads, Money Line Odds & Over Under Points Totals

Check out the NFL Week 6 Spreads and Money Line favorites at all of the  best online sportsbooks below.

Key Week 6 NFL Matchups To Watch 

Buffalo Bills at Kansas City Chiefs, 4:25 p.m, Sunday, October. 16

The two titans of the AFC square up in Week 6 in a game that could have seeding implications down the line. The Bills are currently Super Bowl favorites, with the Chiefs having the second best odds snapping at their heels. Both Josh Allen and Patrick Mahomes are humming in mid season form already. Will we see a shoot out again like the 2022 AFC Divisional Playoffs game where the Chiefs overcame an early deficit to win 42-36. Two juggernaut offenses on show, could it just be the defense that bends rather than breaks that seals this one. You definitely don’t want to miss this one.