NFL Week 5 Picks, Predictions & Betting Lines
Pickswise is your premier destination for NFL Week 5 Picks, Predictions, Lines, and odds.
Our Experts’ track record speaks for itself turning a +23.8 unit profit from NFL Spreads and Money Line Picks over the 2022 season. We have started 2023 even stronger with a 39-22-3 record on NFL Point Spreads, resulting in a handy 27.1pt profit through 4 weeks!!
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NFL Odds Week 5
With many different NFL betting sites available, it’s important to shop the odds and lines each game week. Check out the best NFL Week 5 odds from the Top Online Sportsbooks below. You can find all of the NFL Week 5 Money line odds, Week 5 NFL Spreads, and Week 5 NFL Totals.
Check out the NFL Week 5 Spreads and Money Line favorites at all of the best online sportsbooks below.
NFL Week 5 Spreads, Money Line Odds & Over Under Points Totals
NFL Week 5 Schedule – NFL Games Week 5
| Matchup | Date/Time | Location |
| Chicago @ Washington | Thursday, 10/05 – 20:15 ET | FedExField, Landover, MD |
| Jacksonville @ Buffalo | Sunday, 10/08 – 09:30 ET | Tottenham Hotspur Stadium, London |
| Houston @ Atlanta | Sunday, 10/08 – 13:00 ET | Mercedes-Benz Stadium, Atlanta, GA |
| Carolina @ Detroit | Sunday, 10/08 – 13:00 ET | Ford Field, Detroit, MI |
| Tennessee @ Indianapolis | Sunday, 10/08 – 13:00 ET | Lucas Oil Stadium, Indianapolis, IN |
| New York @ Miami | Sunday, 10/08 – 13:00 ET | Hard Rock Stadium, Miami Gardens, FL |
| New Orleans @ New England | Sunday, 10/08 – 13:00 ET | Gillette Stadium, Foxborough, MA |
| Baltimore @ Pittsburgh | Sunday, 10/08 – 13:00 ET | Acrisure Stadium, Pittsburgh, PA |
| Philadelphia @ Los Angeles | Sunday, 10/08 – 16:05 ET | SoFi Stadium, Inglewood, CA |
| Cincinnati @ Arizona | Sunday, 10/08 – 16:05 ET | State Farm Stadium, Glendale, AZ |
| New York @ Denver | Sunday, 10/08 – 16:25 ET | Empower Field at Mile High, Denver, CO |
| Kansas City @ Minnesota | Sunday, 10/08 – 16:25 ET | U.S. Bank Stadium, Minneapolis, MN |
| Dallas @ San Francisco | Sunday, 10/08 – 20:20 ET | Levi’s Stadium, Santa Clara, CA |
| Green Bay @ Las Vegas | Monday, 11/08 – 20:15 ET | Allegiant Stadium, Las Vegas, NV |