Against the Spread Pick
The Arizona Cardinals will host the San Francisco 49ers here on Thursday Night Football. San Francisco is still undefeated, but I’m still not sold. They’ve faced an incredibly easy slate of opposing offenses, which has made their defense look much better than it actually is. The Cardinals have quietly been very competitive recently, and they’ve won three of their past four games. Kyler Murray has started to make strides in his development, and I think he’s going to be a good match with Kliff Kingsbury for years to come. Arizona is starting to get healthier, while the 49ers are riding high off a blowout win over the Panthers. San Francisco might get a little complacent with their recent victories and playing on the road during a short week, now is a good time to sell-high. Jimmy Garoppolo hasn’t been any good at all, and he’s been getting carried by the defense. There’s no way I could lay this many points with him on the road under the bright lights of national television.
Over Under Pick
I think the under also make some sense here. I think Garoppolo has been mediocre at best, and he should struggle here on the road. It’s a short week, so neither Kingsbury nor Kyle Shanahan are going to have very creative game plans here and I expect both coaches to keep things conservative. The 49ers have one of the league’s top defenses, and Kingsbury isn’t going to want to throw Murray to the wolves. San Francisco’s offensive line is still banged up, and I think Vance Joseph’s defense will play better than expected. Neither team will be lighting up the scoreboard.