NFL Week 10 Picks Against The Spread & Straight Up For 2020

NFL week ten picks against the spread and straight up for every game this week. Get our free NFL week ten expert picks below. Get free NFL picks every week of the season.

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NFL Week 10 Picks Against The Spread & Straight Up For 2020

The home of our free NFL Picks and Predictions for week 10 of the 2020-21 NFL season.

Our expert NFL handicappers, research the entire NFL Week 10 schedule to bring you the best week 10 NFL picks, predictions, and best bets.

The New York Jets, Kansas City Chiefs, Dallas Cowboys, and Atlanta Falcons have their Bye Week, leaving 14, week 10 matches. This page contains all things week 10, including the NFL week 10 spreads, betting lines, Moneyline odds, and our week 10 NFL picks and predictions.

Our expert NFL handicappers research, analyze, and preview every game to find you the best free Picks and NFL Betting lines for week 10.

NFL Week 10 Schedule –  NFL Games Week 10

Thursday, Nov. 12

8:20 p.m. ET – Indianapolis Colts at Tennessee Titans (Thursday Night Football)

Sunday, Nov. 15

1 p.m. ET –Tampa Bay Buccaneers at Carolina Panthers
1 p.m. ET – Houston Texans at Cleveland Browns
1 p.m. ET – Washington Football Team at Detroit Lions
1 p.m. ET – Jacksonville Jaguars at Green Bay Packers
1 p.m. ET – Philadelphia Eagles at New York Giants
1 p.m. ET – Cincinnati Bengals at Pittsburgh Steelers
4:05 p.m. ET – Buffalo Bills at Arizona Cardinals
4:05 p.m. ET – Denver Broncos at Las Vegas Raiders
4:05 p.m. ET – Los Angeles Chargers at Miami Dolphins
4:25 p.m. ET – Seattle Seahawks at Los Angeles Rams
4:25 p.m. ET – San Francisco 49ers at New Orleans Saints
8:20 p.m. ET – Baltimore Ravens at New England Patriots

Monday, Nov. 16

8.15 p.m. ET – Minnesota Vikings at Chicago Bears (Monday Night Football)

NFL Odds Week 10

Our expert handicappers look through the NFL Week 10 schedule and Week 10 odds to bring you the best NFL picks for Week 10.

There are many different betting markets available to sports bettors on any given match, and while our focus here is on the main three markets in the NFL – Moneyline, Against the Spreads, and Points Totals, be sure to check out our NFL Parlays and NFL Prop Bets each week for more alternative NFL Week 10 predictions.

NFL Week 10 Spreads and Moneyline Favorites

The emboldened team denotes the favorite, with their Spread and Moneyline odds also displayed.

Thursday, Nov. 12

8:20 p.m. ET – Indianapolis Colts at Tennessee Titans -2 (-134)

Sunday, Nov. 15

1 p.m. ET –Tampa Bay Buccaneers -6 (-265) at Carolina Panthers
1 p.m. ET – Houston Texans at Cleveland Browns -3.5 (-178)
1 p.m. ET – Washington Football Team at Detroit Lions -4 (-189)
1 p.m. ET – Jacksonville Jaguars at Green Bay Packers -14
1 p.m. ET – Philadelphia Eagles -3 (-173) at New York Giants
1 p.m. ET – Cincinnati Bengals at Pittsburgh Steelers -7.5 (-362)
4:05 p.m. ET – Buffalo Bills at Arizona Cardinals -2 (-130)
4:05 p.m. ET – Denver Broncos at Las Vegas Raiders -5 (-236)
4:05 p.m. ET – Los Angeles Chargers at Miami Dolphins -2.5 (-140)
4:25 p.m. ET – Seattle Seahawks at Los Angeles Rams -2 (-130)
4:25 p.m. ET – San Francisco 49ers at New Orleans Saints -9.5 (-426)
8:20 p.m. ET – Baltimore Ravens -7.5 (-335) at New England Patriots

Monday, Nov. 16

8.15 p.m. ET – Minnesota Vikings -2.5 (-152) at Chicago Bears

Over-under NFL Week 10 Betting Lines

Thursday, Nov. 12

8:20 p.m. ET – Indianapolis Colts at Tennessee Titans O/U 48.5

Sunday, Nov. 15

1 p.m. ET –Tampa Bay Buccaneers at Carolina Panthers O/U 50.5
1 p.m. ET – Houston Texans at Cleveland Browns O/U 53
1 p.m. ET – Washington Football Team at Detroit Lions O/U 46.5
1 p.m. ET – Jacksonville Jaguars at Green Bay Packers O/U 52
1 p.m. ET – Philadelphia Eagles at New York Giants O/U 44.5
1 p.m. ET – Cincinnati Bengals at Pittsburgh Steelers O/U 47.5
4:05 p.m. ET – Buffalo Bills at Arizona Cardinals O/U 56
4:05 p.m. ET – Denver Broncos at Las Vegas Raiders O/U 52
4:05 p.m. ET – Los Angeles Chargers at Miami Dolphins O/U 48
4:25 p.m. ET – Seattle Seahawks at Los Angeles Rams O/U 55.5
4:25 p.m. ET – San Francisco 49ers at New Orleans Saints O/U 50
8:20 p.m. ET – Baltimore Ravens at New England Patriots O/U 42.5

Monday, Nov. 16

8.15 p.m. ET – Minnesota Vikings at Chicago Bears O/U 45

Key Week 10 NFL Matchups To Watch

Buffalo Bills at Arizona Cardinals –  Sunday, Nov. 15, 4:05 p.m. ET  – Arizona Cardinals -2,  O/U 56 points

A game that looks certain to have playoff implications, even if we are just over the mid-point of the season and fireworks are to be expected with 56 points being the highest totals line of Week 10. The Cardinals are still in the hunt for top spot in the super-competitive NFC West and will look to bounce back after giving up a 4th quarter lead in Week 9 in their 34-31 loss to the Miami Dolphins. The Bills actually did the Cardinals a favor in week 9 by trouncing the Seattle Seahawks 44-34 to go to 7-2 on the season and open a 2 game lead at the top of the AFC East, ahead of the Dolphins, and will be keen to keep them at arm’s length. Expect high-quality quarterback play from two young stars of the league in Josh Allen and Kyler Murray with a flurry of points looking likely.

Seattle Seahawks at Los Angeles Rams –  Sunday, Nov. 15, 4:25 p.m. ET – Los Angeles Rams -2, O/U 55.5 points

The NFC West looks as though it will go down to the wire this season so these divisional games, which are always important, look even more so this year. Despite their 44-34 defeat to the Buffalo Bills in week 9, the Seattle Seahawks remain in the driving seat at the top of the division with a 6-2 record, with The Rams just a game back sitting at 5-3. The Seahawks defense has been porous all season and even with Russell Wilson’s MVP-worthy season so far, they must play better to beat good teams. Four of the Rams’ five wins have come against lowly NFC East teams in the Cowboys, Eagles, Giants, and Washington and with losses to better teams in the Bills, 49ers, and Dolphins, they’ll need to bring their A-game here if they are to close the gap and stay in the playoff race.

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