NFL week twelve picks against the spread and straight up for every game this week. Get our free NFL week twelve expert picks below. Get free NFL picks every week of the season.

Thu, Nov 21st - 8:20pm ET:
Indianapolis Colts @ Houston Texans

Indianapolis Colts
Houston Texans
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IND Colts +3.5 Point Spread
-111
Over 45.5 Game Totals
-111

Against the Spread Pick

The Houston Texans will host the Indianapolis Colts on Thursday Night Football. The Colts already beat Houston earlier in the year, and for a few reasons I think they’ll be able to do so again here. A lot of people hopped off the Indianapolis bandwagon after they lost the Dolphins two weeks ago, but that clearly wasn’t representative of who they are as a team. They were playing without Jacoby Brissett, and as soon as they got him back they got right back on track. Indy dominated the Jaguars this past week, and with Brissett back under center they put up 33 points. The Colts also have a clear coaching advantage here, as I’d trust Frank Reich with only a few days of prep all day long over Bill O’Brien. The Texans’ offensive line is still a mess, as evidenced by the six sacks Deshaun Watson took this past week. Houston put up a measly seven points against Baltimore this past week, and now they’re facing a tough Colts defense. Marlon Mack will miss this one with a broken hand, but it shouldn’t matter too much. The Colts still have Jonathan Williams who rushed for 113 yards on only 13 carries last week, and Nyheim Hines to catch passes out of the backfield. Indy will win this one outright.

Over Under Pick

I also lean toward the over in this spot. The Colts are a completely different team with Brissett taking the snaps, and I expect them to dominate against a barely-there Texans secondary. Houston gave up 41 points to the Ravens this past week, and let Lamar Jackson do whatever he wanted the entire game. The defense was atrocious in every aspect, also giving up 263 yards on the ground. The Colts are going to be able to score here no matter what, and I think the Texans will do enough to send this one over. Watson is coming off one of his worst games as a pro, and he should bounce back in this one. He isn’t going to have two terrible games in a row no matter who he is playing.

Sun, Nov 24th - 1:00pm ET:
Pittsburgh Steelers @ Cincinnati Bengals

Pittsburgh Steelers
Cincinnati Bengals
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CIN Bengals +6.5 Point Spread
-111
Under 39.0 Game Totals
-111

Against The Spread Pick

The Pittsburgh Steelers are heading into the jungle this week and they might need some reinforcements. At the moment, the Steelers team is practically looking brand new as James Conner, JuJu Smith-Schuster, Diontae Johnson and suspended Maurkice Pouncey are all heading into this game with low hopes of actually playing. Without those stars, can quarterback Mason Rudolph get the offense going? In the past three games, Rudolph has been lackluster. He has totaled 651 passing yards on 61.5% completion rate along with three touchdowns and five interceptions. Do you trust that offense to beat the Bengals by a touchdown on Sunday to cover? For Cincinnati, they are hoping to get that running game going again as running back Joe Mixon had one of his best games yet this season, rushing for 86 yards, and having over 100 total purpose yards in the loss against the Raiders. I expect the Bengals to get that ground game going as the Steelers are allowing over 100 rushing yards per game. Cincinnati is 8-4 ATS in their last 12 games against an opponent in the AFC North division. A lot of points are up in the air as I’m going to grab them especially against an offense that will be without some key players.

Over Under Pick

With one of the lowest totals of Week 12, Vegas has chalked up a total of 38 points for this Steelers and Bengals. That should not come as a surprise as the Steelers could be led by Rudolph and that’s it on the offense, while the Bengals who are winless on the season are scoring an average of 14.70 points per game. Expect a lot of punts in this game, especially if it takes some time for the Bengals to develop the run game. The Under has hit in seven of the last 10 meetings with the average combined score being 39.10 points. It is going to be a nail bitter, but the Under is the way to go especially without the star power in Pittsburgh. Divisional games should always be favored in the Under category and the Under is 7-1 in Steelers’ last 8 games following a straight-up loss. Take the Under for this low scoring must-watch game.

Sun, Nov 24th - 1:00pm ET:
Oakland Raiders @ New York Jets

Oakland Raiders
New York Jets
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OAK Raiders -2.5 Point Spread
-111
Over 46.5 Game Totals
-111

Against The Spread Pick

Watch out, here come the Oakland Raiders. Head Coach Jon Gruden was criticized early in his gig with the Raiders for trading away his top stars, but it all seems to be working to plan. His young team is slowly coming together for a strong playoff push this year. The Raiders ride into this contest with a 6-4 record and ready to keep their winning streak going as they take on the New York Jets on Sunday. It is going to be a close game without a doubt. All of the Raiders’ victories this year have been by a single possession. It may not have been a dominant win against the Bengals last week, but the Raiders’ defense shone as they totaled five sacks and two forced turnovers. For the past three weeks, the Jets’ offense has been on easy street taking on the Giants, Dolphins and, last week, Redskins. This is going to be a tight game, but the edge has to go to the Raiders as they have been pretty consistent on the road averaging 23.25 points and 254.25 passing yards per game. New York is allowing 264.60 passing yards at home per game as this is the perfect moment for quarterback Derek Carr to shine in a huge win. Take the Raiders in this tight game.

Over Under Pick

The surprise coming into this game has been the return of QB Sam Darnold for the past weeks as he and head coach Adam Gase have found a consistent point in the offense. New York has dropped 34 points in back-to-back weeks and they will surely put up a strong fight against the Raiders. New York will do everything to stay in this game and this matchup has the potential to easily hit the Total in the 3rd quarter. The total has gone OVER in 6 of Oakland’s last 8 games and in 4 of NY Jets’ last 5 games played in November. In the past 10 meetings, the Over has hit seven times with the last three games having a combined 50.67 points per game. With Oakland allowing 31.75 points per game on the road this season, the Over is a great pick in Week 12.

Sun, Nov 24th - 1:00pm ET:
Miami Dolphins @ Cleveland Browns

Miami Dolphins
Cleveland Browns
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MIA Dolphins +10.5 Point Spread
-111
Under 44.5 Game Totals
-111

Against The Spread Picks

The Miami Dolphins’ winning streak has come to an end as Quarterback Ryan Fitzpatrick was sacked seven times in the 37-20 loss at home against the Buffalo Bills. Now the Fins head on the road where they are taking on a Cleveland Browns team that will be without their top defensive star. Myles Garrett has been suspended indefinitely for the rest of the season for slamming a helmet on Steelers’ QB Mason Rudolphs head. That sums up the Browns’ season this year quite nicely. Cleveland has been overhyped all season long and Freddie Kitchens shouldn’t be giving double digits to anyone. Without their star defensive pass rusher, expect Fitzpatrick to throw with ease on this Brown’s team as well as get the running game going. Cleveland gives up an average of 127.2 on the ground. Kitchens has been a major bust for a Cleveland team full of talent and this might be the game where the organization gets tired of it. Take the ton of points and even sprinkle in some money line wagers on the Dolphins.

Over Under Pick

In the last seven meetings between these two , the Under has cashed five times with the average combined score being just below 36 points. These are two lackluster organizations who have yet to play to their full potential and this is going to be a snoozefest with turnovers and horrible play calling. It will be interesting to see whether or not the Browns can rally around their suspended pass rusher or continue to play all over the place. This game SCREAMS the Under as it has cashed 5-2 in the last 7 meetings and 6 of Miami’s last 9 games. Give me the Under here.

Sun, Nov 24th - 1:00pm ET:
Detroit Lions @ Washington Redskins

Detroit Lions
Washington Redskins
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DET Lions -3.5 Point Spread
-111
Under 42.5 Game Totals
-111

Against The Spread Pick

The Detroit Lions are once again looking to construct an offense without quarterback Matthew Stafford. Jeff Driskel will get the nod once again here. However, the Lions will be going up against a much easier opponent compared to last week’s powerhouse of the Dallas Cowboys. The Lions take on the Washington Redskins, who are in a four-game losing streak and have forced rookie QB Dwayne Haskins to learn how to play on Sunday as part of a terrible offense. The Redskins have lost every single home game this season and Haskins has only completing 58.2 percent of his passes for 498 yards, two touchdowns, and five interceptions. There is no way to favor a rookie QB who is still learning the way the league works behind an offensive line that has allowed at least three sacks per game. The Lions are 4-0 ATS in their last 4 meetings and this is a great play for Week 12.

Over Under Pick

Get the pillows and blankets ready as this game will have fans dozing off or turning the channel before the end of the 2nd quarter. However, before you start to fall asleep, make sure you get this Over-Under pick in as it is lined up to be a winner this Sunday. The Detroit Lions might have one of the worst secondaries in the league as they allow 288.50 passing yards per game, and 27.20 points, but with as bad as the Redskins passing offense is, they will not be able to expose the horrible defense. There is no sign of hope in this Redskins offense as they are the worst in the league with averaging 12.50 points per game and 169.50 passing yards. Both teams, especially Washington, will struggle to move the ball downfield which will shift the momentum to Detroit to slowly control and win this game. The Under is 4-0 in the last 4 meetings in Washington and 8-1-2 in the last 11 meetings as the Under is the perfect choice in this one.

Sun, Nov 24th - 1:00pm ET:
Denver Broncos @ Buffalo Bills

Denver Broncos
Buffalo Bills
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DEN Broncos +4.0 Point Spread
-111
Under 37.0 Game Totals
-111

Against The Spread Pick

The Denver Broncos stay on the road once again as they take on the Bills in Buffalo on Sunday. The Bills are rolling high with an impressive 7-3 record, but they have yet to really be tested so far this season. Looking at the Bills’ seven wins this season, they have come against the Titans, Redskins, Giants, Jets, Bengals, and Dolphins (twice). They’ve only beaten one team with a pass defense ranked higher than #27. Buffalo will now take on the Broncos who are currently ranked #6 in defensive efficiency. It may seem like an easy win for the Bills, but the Broncos should be able to move the ball well especially on the ground as Buffalo holds a #27 run defense efficiency as Denver has a #10 run offense for this season. Denver is 4-0 ATS in its last 4 November games as I would even sprinkle in some money line wagers on this Broncos team. Give me the points and the Broncos on Sunday.

Over Under Pick

Both of these teams love to showcase the defense, which is why this is the lowest total of the Week 12 slate. Vegas currently has this game set at 37 total points and this will be one of the tougher Over-Under picks on Sunday. Denver is allowing 19.7 points and 310.8 yards per game compared to the Bills who are allowing 17 points and 304.1 yards per game. This is going to be a dogfight type of game where both teams are going to establish the run, control the clock and win by loads and loads of field goals. This is going to be a huge test for the Bills as they will get pushed around in this game. Do not expect a lot of points here as this game is heading Under. The total has gone UNDER in 13 of Denver’s last 15 games against an opponent in the AFC conference as money should be for the Under here.

Sun, Nov 24th - 1:00pm ET:
Tampa Bay Buccaneers @ Atlanta Falcons

Tampa Bay Buccaneers
Atlanta Falcons
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ATL Falcons -4.5 Point Spread
-111
Over 51.0 Game Totals
-111

Against The Spread Pick

The Tampa Bay Buccaneers live and die by quarterback Jameis Winston and the small amount of momentum they had in the last few weeks has vanished as Winston gave away more free gifts in Week 11. The Buccaneers fell to the  New Orleans Saints at home, 34-17 as Winston finished the day with 313 passing yards, two touchdowns, but four interceptions on the loss. As long as Winston continues to force turnovers on any given Sunday, the lean is always to the opposing team. On the flip side, the Atlanta Falcons are getting hot at the right moment as the defense has been re-born. Looking back at the past three weeks, the Falcons have totaled 13 sacks, four interceptions, and 25 hits on the opposing quarterbacks. They have taken down the playoff-bound Saints and Panthers in back-to-back weeks and Atlanta should have no problem reaching Winston in this game. The defense of the Falcons sacked Panthers QB Kyle Allen five times and picked him off four times. Expect the red-hot Falcons to stay hot and cause problems for Winston. Give me the Falcons in this game.

Over Under Pick

These two teams love to score when they square off and I do not think it will be any different this Sunday. Even though the Falcons defense has been red-hot as of late, the Buccaneers road offense is still one of the most prolific in the league thanks to Winston throwing practically every single down. Tampa Bay is getting an average of 31.20 points on the road per game along with 265 passing yards. In the past 10 meetings, the averaged combine score has been 54.5 total points as Winston and Matt Ryan have slung the ball left and right. Expect wide receivers Mike Evans and Julio Jones to have a historic day as this game has the Over written all over it. The Over is 5-1 in the last 6 meetings in Atlanta and 5-1 in the last 6 meetings.

Sun, Nov 24th - 1:00pm ET:
Seattle Seahawks @ Philadelphia Eagles

Seattle Seahawks
Philadelphia Eagles
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PHI Eagles -1.5 Point Spread
-111
Under 48.0 Game Totals
-111

Against the Spread Pick

A game with potentially huge playoff implications here as the Philadelphia Eagles host the Seattle Seahawks. I’ve been saying it all year, and the Seahawks are pretty overrated. Each of their last two victories have come in overtime, and only one of their eight wins has been by multiple scores. In five of those wins, they’ve won by four or fewer points. They haven’t even played particularly well against bad teams, only beating the Bengals by one point for example. It’s something that is not sustainable at all, and I think they’ll get exposed now that they finally have to take on a good team on the road. Philadelphia has slowly been getting healthier, and they had plenty of chances to beat the Patriots this past week. Seattle’s defense has been a mess recently, giving up at least 24 points in five of their past six games. They even let Falcons backup Matt Schaub throw for over 400 yards on them, and laying less than a field goal with the Eagles is an absolute steal.

Over Under Pick

I also love the under here. Philadelphia has slowly started to become a run first team in recent weeks, and I expect that to continue here. The Eagles’ defense has been criticized a lot recently, but most of that criticism is unwarranted. They just completely shut down Tom Brady last week, and they have given up 17 or fewer points in three straight weeks. Seattle loves to run the ball, but their ground game will get shut down here by Philly’s elite defensive front led by defensive tackle Fletcher Cox. The Eagles’ secondary isn’t nearly as bad as people think it is, and now that they have Ronald Darby back the unit has been playing quite well. The Eagles’ offense on the other hand has looked a bit out of sync, and stud right tackle Lane Johnson is in the concussion protocol. As we saw after he went down against New England, if he misses this one it’s a huge blow to the offense.

Sun, Nov 24th - 1:00pm ET:
Carolina Panthers @ New Orleans Saints

Carolina Panthers
New Orleans Saints
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CAR Panthers +9.5 Point Spread
-111
Under 47.0 Game Totals
-111

Against the Spread Pick

NFC South battle here as the New Orleans Saints host the Carolina Panthers. The Panthers suffered perhaps the most embarrassing loss of Week 11 as they got demolished by the Falcons, and I think they are being undervalued here as a result. Carolina still has a very talented defense, and a spread of pretty much double-digits is vastly inflated. As we saw when the Falcons shockingly beat the Saints outright a couple of weeks ago, it is not wise to lay a huge spread with the Saints against a division opponent. New Orleans was the beneficiary of several lucky bounces and blown calls during their win over the Buccaneers last week. The Saints will also likely be without star cornerback Marshon Lattimore for the second week in a row, and that’s a huge loss. Carolina will be extra fired up for this one coming off their huge loss, and this game is essentially their season. We should see an all-out effort here, and they’ll be able to keep it close at the very least.

Over Under Pick

I also think the under makes a lot of sense here. Carolina quietly has one of the league’s better secondaries, and they also have a strong pass-rush led by rookie Brian Burns. Drew Brees hasn’t been that great since returning from injury, and he has now averaged 6.5 yards per attempt or less in two straight games. On the flip side Panthers quarterback Kyle Allen has struggled mightily recently, tossing four interceptions in their loss to Atlanta. The strength of this New Orleans team right now is their defense and their dominant defensive front. They’ll be content to run the ball a ton with Alvin Kamara and Latavius Murray, and I think this game will be played at a pretty slow pace.

Sun, Nov 24th - 1:00pm ET:
New York Giants @ Chicago Bears

New York Giants
Chicago Bears
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NY Giants +6.5 Point Spread
-116
Over 40.5 Game Totals
-111

Against the Spread Pick

Not exactly a top-flight matchup here as the Chicago Bears host the New York Giants. It’s unclear if Mitch Trubisky or Chase Daniel will be starting here for Chicago, but oddsmakers have determined that it doesn’t matter. Daniel came on in relief of Trubisky toward the end of their loss to the Rams, and he looked equally as awful. I’m not sure I would make the Bears this large of a favorite against just about anybody right now, and the Giants had the bye week to prepare for this one. Chicago’s defense hasn’t been nearly as good as it was last year, and Daniel Jones should be able to have a little bit of success. I expect Chicago’s defense to not be nearly as intense here, as they deal with the disappointment of just about being eliminated from the playoff race. The Bears will still be without stud defensive lineman Akiem Hicks, and the run defense hasn’t been the same without him. As such, Saquon Barkley should be able to break some big runs here. Take the points.

Over Under Pick

You won’t feel good, but I think you have to take the over here. This number is simply too low for how the Giants have been playing recently. Jones has been putting up some big numbers at times, but he is also extremely turnover-prone which creates easy opportunities for the opposing side. The Giants have one of the worst defenses in the entire league, and they’ve given up at least 27 points in six straight games. As I said above the Bears’ defense isn’t as good without Vic Fangio coordinating it, and I think the Giants will surprise some people on offense here.

Sun, Nov 24th - 4:05pm ET:
Jacksonville Jaguars @ Tennessee Titans

Jacksonville Jaguars
Tennessee Titans
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JAX Jaguars +3.0 Point Spread
+100
Under 41.5 Game Totals
-111

Against The Spread Pick

The Jacksonville Jaguars were hoping to get a grand welcoming from quarterback Nick Foles who returned from injury against the Indianapolis Colts last week but it was quite the opposite in the 33-13 beatdown. Now the Jaguars are hoping to start fresh once again as they take on the Titans on the road in Week 12. For the Titans, they have already welcomed a fresh start to the organization with the benching of QB Marcus Mariota who has taken the Titans to a 3-1 record since taking over the team. He has led Tennessee to score at least 20 points in every game and has been the far superior option compared to Mariota. However even though the Titans have been winning as of late, they have not come easy as they have won their last three games by a combined 10 points. Giving three points to a Jaguars team that loves to run and control the clock on the road might be the perfect pairing. Jacksonville is averaging 153.20 rushing yards per game on the road which is 3rd best in the league, and 69.40 plays which is best in the league. They are going to control the game and make Tennessee change up their game-plan. I love the points here as the Jags are 5-2 ATS in their last 7 games against an opponent in the AFC conference.

Over Under Pick

As stated above, the Jaguars love to control that clock on the road and will do the same against the Titans. With both teams favoring the run as of late, do not expect any big passing plays nor scoring opportunities until both teams reach the RedZone. This is going to be the battle of the offensive lines as both teams are averaging at least 113 rushing yards per game. A low scoring game should be on the horizon in this one as The total has gone UNDER in 4 of Jacksonville’s last 5 games against an opponent in the AFC South division and in the past three of four meetings. Love the Under in this game as both teams establish the run game and do not worry about the clock.

Sun, Nov 24th - 4:25pm ET:
Dallas Cowboys @ New England Patriots

Dallas Cowboys
New England Patriots
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DAL Cowboys +6.0 Point Spread
-105
Under 46.0 Game Totals
-111

Against the Spread Pick

We only get the Dallas Cowboys vs. New England Patriots matchup once every four years, so this is a treat. It’s been clear for a while, but people are only now starting to realize that there is something wrong with New England, particularly on offense. Tom Brady had another bad game this past week against the Eagles, where he was lucky to escape without several interceptions. New England coasted on a very easy schedule to start the season, which included a six-game stretch against the Dolphins, Jets, Bills, Redskins, Giants, and Jets again. The offense looks average-at-best and while the defense is still very good, they aren’t quite as good as they looked against incredibly weak competition. The Cowboys have their best offense in years, and they just dropped 35 points for the third time in four games this past week. Dak Prescott is a legit MVP candidate, and he just threw for 444 yards and three touchdowns on the road against the Lions. Grab the points here.

Over Under Pick

 I’m also playing the under here. Dallas might have given up 27 points this past week but that number is misleading, and they held Detroit only 312 yards of total offense. New England still has the League’s top defense, and they just held the Eagles to 10 points this past week. In the second half against Carson Wentz, they didn’t let up a single score. Brady has clearly lost a step, and he is averaging only 6.8 yards per attempt this season. The Patriots have virtually no ground game either, as they are only averaging 3.3 yards per carry as a team. Prescott has been great, but his huge games have come against poor secondaries for the most part.

Sun, Nov 24th - 8:20pm ET:
Green Bay Packers @ San Francisco 49ers

Green Bay Packers
San Francisco 49ers
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GB Packers +3.0 Point Spread
+100
Under 46.5 Game Totals
-111

Against the Spread Pick

Sunday night football here as the San Francisco 49ers host the Green Bay Packers. The Packers are coming off their bye week, while the 49ers escaped with a narrow win over Arizona. The 49ers trailed virtually the entire game, and they were lucky to get out of there with a victory. The 49ers might be 9-1, but they sure haven’t played like it. Their wins have come against teams like the Buccaneers, Bengals, Browns, Redskins, and Cardinals, so I haven’t been particularly impressed. The only really good team they played this season was the Seahawks, and they lost at home. Green Bay had an extra week to prepare for this one, and Matt LaFleur should have a good script schemed up for Aaron Rodgers. San Francisco’s defense was never as good as the media made it out to be, and they have now given up at least 25 points in three straight games. They aren’t going to shut down Rodgers here, and Green Bay is going to win this one.

Over Under Pick

The under also makes some sense. Neither offense has been as good as they’ve been hyped up to be, and I think we see a defensive struggle here. The 49ers are a run-heavy team, and I expect them to pound of the ball a ton. Jimmy Garoppolo hasn’t been very good this season, and over his past two games he has thrown three interceptions while taking seven sacks. Garoppolo hasn’t been tested by too many tough defenses, and this Green Bay unit is arguably the best one he’s faced all season. Rogers has been mediocre his past two games, and I don’t think the Packers’ offense is going to explode either.

Mon, Nov 25th - 8:15pm ET:
Baltimore Ravens @ Los Angeles Rams

Baltimore Ravens
Los Angeles Rams
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BAL Ravens -3.0 Point Spread
-116
Under 46.5 Game Totals
-111

Against the Spread Pick

The Los Angeles Rams will host a primetime game for the second straight week here as they take on the Baltimore Ravens. The Ravens have been on fire recently, and they can establish themselves as the team to beat in the entire league if they win this one. The Rams “bounced back” with a win over the Bears last week, but I’m not buying any talk of a resurgence. They were downright awful before that, losing in embarrassing fashion to the Steelers the week prior. Los Angeles still doesn’t have a competent offensive line, and Jared Goff is not the answer under center. The Ravens have been an unstoppable force, most recently beating down the Texans by 34 points. The Ravens got whatever they wanted on the ground in that one, rushing for 263 yards, and they shouldn’t have much trouble moving the ball here as well. Lamar Jackson is the MVP front-runner, and I think he’ll be able to run on Los Angeles’ linebackers. Lay the points here.

Over Under Pick

I like the under even more in this spot. Baltimore’s defense has been coming on strong ever since the Marcus Peters trade, and they just forced Deshaun Watson to have one of his worst games as a pro. Peters is playing against his old team, and I think he’ll take advantage of the opportunity for revenge. Baltimore sacked Watson six times last week, and their pass-rush should similarly be able to get after Goff here. The defense has become the strength of this Rams team, and they’ve given up 17 or fewer points in four straight games. With Jalen Ramsey, Aaron Donald, Dante Fowler, Clay Matthews, Eric Weddle and others, Los Angeles has a ton of talent on defense.

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