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AC Milan vs Inter Milan Champions League soccer predictions and UCL best bets for Wednesday 5/10: Inter draw first blood against AC

AC Milan vs Inter Milan Champions League soccer predictions and UCL best bets for Wednesday 5/10: Inter draw first blood against AC

Alex Hilton
Alex HiltonAuthor
UpdatedSep 15, 2026
Reading time2 min

The second Champions League semifinal gets underway on Wednesday and it features two Italian clubs that know each other very well, as Inter Milan battle fierce rivals AC Milan at the San Siro. Both teams have gone through a rough period over the past decade but they are now back in the big time and will be fully motivated on advancing to the final of Europe’s biggest club soccer competition. Which team will secure the momentum in this first leg? You can watch the game on CBS and Paramount+ at 3:00 pm ET on Wednesday, and make sure you also check out our soccer predictions for every Champions League, English Premier League and MLS game.

You can bet any of our soccer predictions at FanDuel Sportsbook, which has a great new-customer offer to take advantage of. If you sign up for FanDuel right now, you can get $150 in bonus bets following an initial wager of just $5! Click here to join FanDuel right now.

AC Milan vs Inter Milan best bet: Inter Milan tie no bet (-142)

This game should be a Derby della Madonnina unlike any other and it could go the way of Inter, who can take the initiative by winning this Champions League semifinal first leg against their city rivals AC Milan. The Nerazzurri have hit top form in recent weeks, winning their last 5 straight matches in all competitions and scoring 15 goals in the process. They possess greater firepower than AC Milan, who may be without main attacking threat Rafael Leao.

Inter have won their last two games against AC — 3-0 in the Coppa Italia in January and 1-0 in Serie A the following month — and look the best bet with the insurance in the tie no bet market.

You can bet on today’s soccer action over at DraftKings Sportsbook, which has a great sign-up offer where you can bet $5 and get $150 in bonus bets if your team wins! Click here to take advantage and claim your bonus bets right now.

Pickswise is the home of free Soccer predictions, with soccer picks from the Premier League, MLS, Champions League and the Europa League, all season long.

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