NFL betting guide: Expert 2022 Week 5 NFL picks, predictions, odds & best bets

Cincinnati Bengals wide receiver Ja'Marr Chase (1) reacts after moving the ball forward against the Pittsburgh Steelers in the first half at Paycor Stadium.
Photo of Phil Agius

Phil Agius


Show Bio

I've been writing about the NFL and a host of other sports for the UK's top daily betting paper the Racing Post for more than 20 years. An incurable Browns fan (1-31 survivor), I also specialise in all kinds of motorsport betting including F1, MotoGP, IndyCar and NASCAR. For Phil Agius media enquiries, please email

Welcome to the Pickswise NFL Week 5 betting guide. The 2022 NFL season has reached this point with just the 4-0 Philadelphia Eagles remaining unbeaten while, after the Las Vegas Raiders secured their first win last week, the 0-3-1 Texans are the only winless team. Week 5 got off to a low-key start, to put it kindly, with the Colts beating the Broncos 12-9 on Thursday Night Football. Things can only get better after that, and if the previous Sunday slates this season are anything to go by we will be in for a real treat again.

This week’s slate — like last week’s –starts early with the second game at Tottenham Hotspur Stadium between the Giants and Packers. The Giants have plenty of experience of playing in London, having beaten the Dolphins in the very first regular-season game played there in 2007, while the Packers are becoming the 32nd and final team to make their first visit to England. The extended Sunday slate starts at 9:30am ET and runs all the way through to Sunday Night Football!

We have a couple of rookies set to make their first career starts as Pittsburgh goes with Kenny Pickett against the Bills and the Patriots turn to Bailey Zappe against the Lions. There are also some nice divisional rivalries including Bears vs Vikings, Falcons vs Buccaneers and Dolphins vs Jets, plus another on Sunday Night Football as the Bengals take on the Ravens.

Our experts have done the hard work so you have everything you need to bet better and get the right results. This is your one-stop shop for everything you need to make the most of your NFL Sunday — and Monday night’s Raiders vs Chiefs game. Don’t forget to check out our great new game previews, which now include prop picks, projections, trends and Same Game Parlays.

Our handicappers have made a fantastic start to the 2022 season and Week 4 saw us go an amazing 13-2-1 on our spread picks! Also, be sure to check out our EXCLUSIVE TD scorer odds boost for Week 5 from DraftKings Sportsbook.

NFL Week 5 picks

  • NFL picks against the spread and total for EVERY Week 5 game – we went 13-2-1 last week!
  • NFL best bets – we have an 18-6 record on our 3-star plays this season
  • NFL parlays

NFL Week 5 expert betting picks and predictions

NFL Week 5 prop bets

 NFL Week 5 Promo Codes

  • BetMGM: Bet $10 Win $200 if either NFL Team scores a TD, Claim HERE
  • DraftKings: Bet $5+ On Any NFL Pre-Game ML, Get $200 If Your Bet Wins, Claim HERE
  • FanDuel: No Sweat First Bet up to $1,000 on NFL, Claim HERE
  • Caesars: Up To $1,250 Back On Your First Bet + 1000 Tier Credits + 1000 Reward Credits®, Claim HERE
  • PointsBet: Get 4x $200 Second-Chance Bets For The NFL, Claim HERE

Find all the latest Sportsbook Promo Codes and Bonuses for NFL Week 5, including sportsbooks live in your state.

NFL Week 5 big-game predictions

Watch Pickswise Playbook!

Our weekly NFL show Pickswise Playbook, presented by Superbook Sports, is hosted by Lauren Jbara and Jared Smith and features former NFL player Tank Williams as this week’s guest.

Pickswise is the home of free NFL Picks and NFL Odds. Check out the latest NFL Prop Bets and NFL Parlays as well as expert NFL Underdog Picks and NFL Computer Picks.

By signing up you agree to our terms and privacy policy