NFL betting guide: Expert Week 5 NFL predictions, picks, odds & best bets

Welcome to the Pickswise NFL Week 5 betting guide! On the heels of an exciting first 4 weeks, we’ve got another terrific weekend of football in store for us, headlined by a couple of marquee matchups in the AFC (Ravens vs Bengals & Bills vs Texans).

What’s in store for Sunday? Well, our experts have done the hard work so you have everything you need to bet better and get the right results. This is your one-stop shop for everything you need to make the most of your NFL weekend. You can also read our great NFL predictions for every game on the Week 5 slate of the NFL regular season.

NFL Week 5 picks 

• NFL picks against the spread and total for EVERY Week 5 game 
• NFL best bets  
• NFL parlays 

NFL Week 5 expert betting picks and predictions 

• NFL expert’s best bets
• NFL Week 4 mega parlay (+841 odds!) 
• NFL SNF Cowboys vs Steelers SGP

NFL Week 5 prop bets 

• NFL London game prop bets – from Prop Holliday
• Week 5 touchdown scorer best bets 
• Sunday player prop best bets  

NFL Week 5 big-game predictions 

• Ravens vs Bengals predictions
• Bills vs Texans predictions
• Panthers vs Bears predictions
• Browns vs Commanders predictions
• Cardinals vs 49ers predictions
• Packers vs Rams predictions