NFL Week 10 best bets, picks and predictions on Prophet Exchange: Titans send the Broncos packing

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Caleb Wilfinger


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Deputy Editor for Pickswise with years of experience handicapping and giving out winning picks. Lover of all US sports and Southampton FC. For Caleb Wilfinger media enquiries, please email
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We have arrived at Week 10 of the NFL season, and it would be a good time to take your football betting to Prophet Exchange.

If you are not familiar with sports betting exchanges, you might want to take a look at this guide to betting with Prophet Exchange in addition to exchange betting terminology before diving in and making your wagers. As the name suggests, a sports betting exchange is a platform for exchanging bets from one bettor to another without the need for a bookmaker to set the odds for each outcome. Users can either set their own odds and hope another user will be willing to take the bet, or they can peruse the market to see what odds other users are willing to make and jump on one of those offers.

For example, this Sunday the Seahawks are +135 underdogs against the Buccaneers (-160) at most sportsbooks. At those ‘books, you can only bet on those 2 teams at those 2 prices. With a sports betting exchange, however, that’s not the case. You could try to get the Seahawks +160 and if someone is willing to take your offer and grab the Buccaneers at -160 then a match is made.

One especially important aspect of Prophet Exchange that must be noted is against the spread odds are all available at +100 odds as opposed to the -110 juice you generally encounter at most sportsbooks. That is because in an exchange you are betting against other bettors instead of against the sportsbook; and afterwards, Prophet Exchange takes a commission from the winnings. Needless to say, making a wager at +100 instead of -110 is a huge advantage – especially adding over time.

With that, let’s take a look at some best bets for NFL Week 10 that can be made at Prophet Exchange.

Tennessee Titans -2.5 (+100) over Denver Broncos

The Broncos’ rushing attack has been in trouble since the day Javonte Williams tore his ACL and they have barely cracked 100 yards per game on the ground over the past three weeks. That means Wilson is going to have to carry this offense through the air. That’s actually not that tall an order as the Titans secondary grades out as one of the worst in the league, allowing 275.6 passing yards per game and 15 passing touchdowns on the season. Wilson has struggled to keep this offense moving with any real consistency, but this match-up certainly tilts it in his favor.

Both Denver and Tennessee have played some close games all year, but with a 2.5-point spread favoring the Titans, we have to favor the home team. Tennessee is 6-2 against the spread this season and have covered in each of the last five straight. That’s what happens when you can run the ball effectively. Denver, meanwhile, is 3-5 against the spread this season and struggles against the run. Whether Wilson shines or not, if you can’t stop Henry, you can’t control the game.

Be sure to check out our full Titans vs Broncos predictions

Minnesota Vikings +4.5 (+100) vs Buffalo Bills

If you believe Josh Allen will sit out this week, then bet the Vikings right now before the line drops any further. And even if he does play, you can bet the Vikings down to +3.5, but any lower and it’s a no-bet. Case Keenum is the Bills’ backup quarterback and while he is comfortable in Sean McDermott’s offense, and him starting could add some emotion with him and Stefon Diggs playing against their former team, he is far from the passer Allen is and will likely be exposed against an underrated Vikings defense.

The Bills’ defense remains unchanged with the Allen situation, but they are still dealing with injuries to their secondary as safety Jordan Poyer and cornerback Tre’Davious White are both questionable for Sunday’s game. The Bills’ run defense is also having recent issues, allowing the sixth-most rushing yards per game over the last three weeks. Expect the Vikings to come out strong with Dalvin Cook and allow that to open up the play-action downfield. The game should stay close, but no Allen or a limited Allen tips the scales in Minnesota’s favor.

Be sure to check out our full Vikings vs Bills predictions

Chicago Bears -2.5 (+100) over Detroit Lions

Make no mistake about it, even though the Lions are coming off a rare victory, it’s not like they have much momentum. Head coach Dan Campbell’s team is 2-6 overall, 1-5 in its last 6 and now it must go back on the road — where it is 0-3 SU and 1-2 ATS at the halfway point of this 2022 campaign. Detroit’s 2 wins have come at the expense of Washington and Green Bay, who are a combined 4 games under .500.

Even though the Bears are in the midst of a 2-game skid, they should be the team playing with confidence. Chicago destroyed New England 33-14 in Week 7 and rebounded from an understandable loss at Dallas on a short week to push Miami from start to finish this past Sunday. The Dolphins held on 35-32, but Justin Fields went crazy to the tune of 178 rushing yards and 4 total touchdowns (1 through the air, 3 on the ground).

Be sure to check out our Bears vs Lions predictions

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