NFL betting guide: Expert 2022 Week 7 NFL picks, predictions, odds & best bets

UpdatedSep 15, 2026

Reading time2 min

Welcome to the Pickswise NFL Week 7 betting guide. The 2022 NFL season has reached this point with just the 6-0 Philadelphia Eagles remaining unbeaten, and they will remain unbeaten as Philadelphia is on a bye this week. Week 7 got off to a hot start, with the Cardinals beating the Saints in a high-scoring affair on Thursday Night Football. If the previous Sunday slates this season are anything to go by then we will be in for a real treat again.

This week’s slate is highlighted by a Chiefs vs 49ers matchup, while other intriguing games include the Giants vs Jaguars, Falcons vs Bengals, Chargers vs Seahawks and Colts vs Titans.

Our experts have done the hard work so you have everything you need to bet better and get the right results. This is your one-stop shop for everything you need to make the most of your NFL Sunday — and Monday night’s Bears vs Patriots game. Don’t forget to check out our great new game previews, which now include prop picks, projections, trends and Same Game Parlays.

Our handicappers have made a fantastic start to the 2022 season, as we are 26-8 on our best bets this season! Be sure to also check out our EXCLUSIVE TD scorer odds boost for Week 7 from DraftKings Sportsbook.

NFL Week 7 picks

NFL picks against the spread and total for EVERY Week 7 game
NFL best bets – we have an 26-8 record on our 3-star plays this season
NFL parlays

NFL Week 7 expert betting picks and predictions

NFL Week 7 prop bets

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Find all the latest Sportsbook Promo Codes and Bonuses for NFL Week 7, including sportsbooks live in your state.

NFL Week 7 big-game predictions

Chiefs vs 49ers
Seahawks vs Chargers
Falcons vs Bengals
Colts vs Titans
Giants vs Jaguars

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