The Ultimate NFL Betting Guide For Week 1: Everything you need to win

Kansas City Chiefs quarterback Patrick Mahomes (15) celebrates during the fourth quarter in the AFC Championship Game against the Buffalo Bills at Arrowhead Stadium.
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Andrew Ortenberg


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I'm an NFL handicapper here at Pickswise who was raised in a household full of sports fanatics. Since I unfortunately never had LeBron James' jumping ability I wasn't able to make it to the NBA, and chose writing about sports as the next best thing. An avid sports bettor myself, I'm excited to get to write about the industry as it gets set to take off across the country. Buckle up. For Andrew Ortenberg media enquiries, please email
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Welcome to the Pickswise NFL Week 1 betting guide — our experts have done the research so you have everything you need to beat your book below! The 2021 NFL season will have its first full slate on Sunday, and this is your one-stop shop for all the info you need to inform your wagering.

NFL Week 1 picks

Pickswise Playbook

Make sure you check out Pickswise Playbook, our brand new weekly NFL betting show with Chris Rose, Ross Tucker and Jared Smith as they look to make your next bet better! Out every Thursday

Week 1 betting articles

Week 1 big game same game parlays

We have same game parlays for every single NFL game, which you can find in our NFL news tab, but here are a select few from the biggest games of Week 1:

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