Pickswise
College football betting guide: Expert Week 4 CFB predictions, picks, odds & best bets

College football betting guide: Expert Week 4 CFB predictions, picks, odds & best bets

Andrew Wilsher
Andrew WilsherAuthor
UpdatedSep 15, 2026
Reading time2 min

College football Week 4 has arrived, and right here at Pickswise, our team of expert CFB handicappers have you covered for all of the big matchups! After a number of shocking upsets and big storylines in the season so far, what will Week 4 have in store? You can find out our college football picks and CFB predictions for the huge games on Saturday, September 21, plus all our parlays and Same Game Parlay picks to help you bet better!

Let’s dive in.

College football Week 4 best bets

Make sure you find out our expert’s best bets of the day after they finished last season up +10.45 units.

College football Week 4 parlays

Lock in our CFB Week 4 parlay for Saturday’s games, plus we’ve got SGPs for Tennessee vs Oklahoma and USC vs Michigan.

If you’re looking to bet on our CFB Same Game Parlays, we recommend using Caesars Sportsbook. You’ll find EVERY college football game AND some of the best odds available, and right now new users can sign up by clicking here and earn first-bet protection up to $1,000!

College football Week 4 picks

Below, you’ll find our game previews and NCAAF predictions for the hottest matchups in Week 4:

  • Florida vs Mississippi State prediction
  • Kansas vs West Virginia prediction
  • Marshall vs Ohio State prediction
  • NC State vs Clemson prediction
  • Georgia Tech vs Louisville prediction
  • Kent State vs Penn State prediction
  • USC vs Michigan prediction
  • UCLA vs LSU prediction
  • Utah vs Oklahoma State prediction
  • Tennessee vs Oklahoma prediction
  • Baylor vs Colorado prediction
  • UL Monroe vs Texas prediction
  • Purdue vs Oregon State prediction
  • Kansas State vs BYU prediction