NFL betting guide: Expert 2022 Week 18 NFL picks, predictions, odds & best bets

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Phil Agius


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I've been writing about the NFL and a host of other sports for the UK's top daily betting paper the Racing Post for more than 20 years. An incurable Browns fan (1-31 survivor), I also specialise in all kinds of motorsport betting including F1, MotoGP, IndyCar and NASCAR. For Phil Agius media enquiries, please email

Welcome to the Pickswise NFL Week 18 betting guide! We have made it to the end of the NFL regular season, although the mood around the league is more somber than celebratory this year after the upsetting scenes in Cincinnati on Monday night. Happily, Bills safety Damar Hamlin is now on the road to recovery and the NFL action resumes this weekend.

After Saturday’s AFC games — Chiefs vs Raiders and Titans vs Jaguars — there are no fewer than 14 games on Sunday’s slate. It’s the trickiest week of the season with doubts over team lineups and motivations, including some which could change depending on earlier results, but if this crazy season has taught us anything, we know there will be things you don’t expect to happen that will happen!

There are 8 games on Sunday’s 1:00pm slate with the Bills (vs Patriots) and Bengals (vs Ravens) both returning to the field, while the first pick in the draft will be decided by the result of the Texans vs Colts and (if the Texans win) Vikings vs Bears games. The 5-game late afternoon slate will see the NFC East title heading to either the Eagles or Cowboys, while the 49ers are chasing their 10th straight win when they meet the Cardinals. The final Sunday Night Football game of the season between the Lions and Packers could be a shootout for the final playoff place, depending on the result of the earlier Rams vs Seahawks game.

Our experts have done the hard work so you have everything you need to bet better and get the right results. This is your one-stop shop for everything you need to make the most of your NFL weekend. You can also read our great NFL predictions for every game on the final slate of the NFL regular season.

NFL Week 18 picks

  • NFL picks against the spread and total for EVERY Week 18 game – we are 143-107-6 on sides for +38.6 units of profit this season!
  • NFL best bets – we have a 48-38 record on our 3-star plays this year
  • NFL parlays

NFL Week 18 expert betting picks and predictions

NFL Week 18 prop bets

NFL Week 18 Promo Codes

Find all the latest Sportsbook Promo Codes and Bonuses for NFL Week 18, including sportsbooks live in your state. 

NFL Week 18 big-game predictions

Ohio bettors — check out the best Ohio sportsbook sign-up offers and bonuses before betting on the Bengals or Browns games!

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