NFL Week 3 Opening Odds, Betting Lines, and spreads: Rams have value as underdog

Los Angeles Rams wide receiver Tutu Atwell (5) reacts after catching a pass against the San Francisco 49ers during the first half at SoFi Stadium.
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NFL Week 2 is nearly over, but first, we have a Monday Night Football doubleheader that features the New Orleans Saints taking on the Carolina Panthers and the Cleveland Browns facing the Pittsburgh Steelers. Looking ahead at Week 3, there are certain teams we would not have expected to still be searching for their first win, like the Bengals, Chargers and Vikings. 

Most sportsbooks announced game lines for the next week on Sunday night, so here are the opening lines for Week 3. Make sure you keep checking our NFL predictions as we add our picks on the side and total for every game throughout the week.

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NFL Week 3 opening lines and odds

Odds available at FanDuel Sportsbook at time of publishing.

New York Giants +10 (-110) vs San Francisco 49ers -10 (-110) – Thursday Night Football
Atlanta Falcons +4.5 (-108) vs Detroit Lions -4.5 (-112)
Houston Texans +9 (-110) vs Jacksonville Jaguars -9 (-110)
Buffalo Bills -6.5 (-110) vs Washington Commanders +6.5 (-110)
New England Patriots -2.5 (-105) vs New York Jets +2.5 (-115)
Los Angeles Chargers -1 (-110) vs Minnesota Vikings +1 (-110)
Indianapolis Colts +8 (-110) vs Baltimore Ravens -8 (-110)
New Orleans Saints +2 (-110) vs Green Bay Packers -2 (-110)
Tennessee Titans +4.5 (-110) vs Cleveland Browns -4.5 (-110)
Carolina Panthers +4.5 (-110) vs Seattle Seahawks -4.5 (-110)
Chicago Bears +12.5 (-110) vs Kansas City Chiefs -12.5 (-110)
Dallas Cowboys -12.5 (-110) vs Arizona Cardinals +12.5 (-110)
Denver Broncos +6.5 (-105) vs Miami Dolphins -6.5 (-115)
Pittsburgh Steelers -1 (-110) vs. Las Vegas Raiders +1 (-110) – Sunday Night Football
Philadelphia Eagles -6.5 (-110) vs Tampa Bay Buccaneers +6.5 (-110) – Monday Night Football
Los Angeles Rams +6.5 (-110) vs Cincinnati Bengals -6.5 (-110) – Monday Night Football

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Best early bet for NFL Week 3: Rams +6.5 over Bengals (-110)

The Bengals continue to get the respect of a team that they used to be, not the team they are now. Joe Burrow and the Bengals fell to 0-2 after their Week 2 loss to the Ravens, and Burrow still didn’t look like himself. He was expected to bounce back and have a classic Joe Burrow game, but it’s clear that his calf injury is limiting his performance. He can’t scramble out of the pocket the way we’re used to seeing and it was announced that he reaggravated his calf injury during the loss. Meanwhile, the Rams played the 49ers in Week 2 and were competitive for the entire game. It was an untimely interception by Matthew Stafford that allowed San Francisco to win their second game of the season, so the Rams should be getting more respect than this spread. I had the Rams projected as +5 underdogs, so there’s plenty of value at +6.5.

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