Pickswise
Best 2021 NFL Draft bets for first positional draftee: Etienne ready to be first running back called

Best 2021 NFL Draft bets for first positional draftee: Etienne ready to be first running back called

Andrew Ortenberg
Andrew OrtenbergAuthor
UpdatedSep 15, 2026
Reading time3 min

The start of the 2021 NFL Draft is so close we can taste it. There is a seemingly endless string of props to wager on, and we’ll be getting you prepped right up until Roger Goodell calls Trevor Lawrence’s name. There are of course over/under on individual players, and you can check out our favorite of those plays here.

Mock draft season is in full swing as well, and we’ve got our own one of those here. One of the most popular bets each year is wagering on which player in a given position group will be drafted first. That’s what we’ll be taking a look at today. Without further ado, let’s dive in:

First Running Back drafted – Travis Etienne (+150)

Getting Etienne at this much plus-money has significant value. Najee Harris got most of the attention late in the college football season, but Etienne is by far the most ready for an NFL passing game. In today’s NFL, where it’s so important for running backs to be skilled at pass protection and catching balls out of the backfield, Etienne has a big advantage. Most of the plugged-in guys who I trust seem to think it’s really close to 50/50 between Harris and Etienne, so there’s no way I could bet -225 odds with Harris here.

First Offensive Lineman drafted – Rashawn Slater (+250)

I continue to think that teams aren’t quite as high on Penei Sewell as the media is. Buzz has been building for a while now that plenty of clubs have Slater over Sewell on their boards. Daniel Jeremiah of NFL Network had Slater going first in his penultimate mock, and he’s got some of the best draft sources out there. This one also feels like closer to a toss-up, and getting +250 is a steal. Playing for Northwestern, Slater flew a bit under the radar with national audiences, but that certainly isn’t the case in league circles.

First Linebacker drafted – Jeremiah Owusu-Koramoah (+700), Zaven Collins (+1000)

This is a fade of Micah Parsons, who is priced at a very steep -400. As such, I recommend taking a little bit of both Owusu-Koramoah and Collins if you’re looking for a bigger payday. I think Parsons is going to slip, as his stock has seemingly dipped significantly over the past month or two. Rumors of off-field issues persist. Jeremiah had him going 15th, just two spots ahead of Owusu-Koramoah. That’s too close to warrant this kind of price difference.

Meanwhile Tony Pauline of ProFootballNetwork, another plugged-in draft insider, has Collins going 16th to the Cardinals in his final mock. He said everything he’s heard the past couple weeks indicates Collins will be Arizona’s pick at 16. If that’s the case, there’s certainly better than a 10/1 chance that he goes ahead of Parsons, who could really tumble.

Be sure to check out Pickwise’s other 2021 NFL Draft content:

Pickswise is the home of free expert NFL Picks and NFL Predictions. Check our season previews and NFL Futures Bets leading up to the NFL Season, including our favorite NFL Prop Bets for the 2021 season.

Exclusive Offers
See all
Polymarket — Deposit $10, Get a $50 Trading Bonus
Polymarket
PolymarketDeposit $10, Get a $50 Trading Bonus
$50
Novig — Deposit $10, Get $25 in Trade Credits
Novig
NovigDeposit $10, Get $25 in Trade Credits
$25
Underdog — First-Time Deposit Match + Keep Your $1,000,000
Underdog
UnderdogFirst-Time Deposit Match + Keep Your $1,000,000
$1,000,000
Onyx Odds — Spend $10, Get $111 in Bonus Picks
Onyx Odds
Onyx OddsSpend $10, Get $111 in Bonus Picks
$111
Bet365 — Bet $10, Get $365 in Bonus Bets, Win or Lose
Bet365
Bet365Bet $10, Get $365 in Bonus Bets, Win or Lose
$365
Fanatics — Bet $20, Get $350 in FanCash
Fanatics
FanaticsBet $20, Get $350 in FanCash
$350
BetMGM — Get Up to $1500 in Bonus Bets if your First Bet Does Not Win
BetMGM
BetMGMGet Up to $1500 in Bonus Bets if your First Bet Does Not Win
$1,500
ProphetX — Trade $50, Get $75
ProphetX
ProphetXTrade $50, Get $75
$75
Rebet — Get a 100% Deposit Match up to $100
Rebet
RebetGet a 100% Deposit Match up to $100
$100
FanDuel — Bet $5, Get $350 in Bet Reset Tokens over 7 Days
FanDuel
FanDuelBet $5, Get $350 in Bet Reset Tokens over 7 Days
$350
When you click our links to visit an operator and sign up, we may receive a commission at no extra cost to you. This financial relationship helps support our site.
Pickswise
Get exclusive 
free sports picks
to your email
subscriber 1
subscriber 2
subscriber 3
18K users have
already subscribed
Enter your email address
By signing up you agree to our terms and privacy