Sunday Night Football Kansas City Chiefs vs Los Angeles Chargers NFL predictions, picks, odds & spreads: Expect a close game in LA

Los Angeles Chargers quarterback Justin Herbert (10) throws a pass against the Kansas City Chiefs in the second half at SoFi Stadium.
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The Kansas City Chiefs will take on the Los Angeles Chargers on Sunday Night Football in this Week 11 matchup. In recent years, the Chargers have been able to keep things very competitive against Patrick Mahomes and company, but this AFC West showdown has lost a bit of its luster this year. Los Angeles is struggling on offense, while the Chargers defense has not performed as expected. Nonetheless, they should be healthier than recent weeks for this important contest.

Our NFL expert has picks, predictions and best bets for this matchup, so let’s break it all down.

Be sure not to miss any of our NFL picks for Week 11 — we’re 83-64-3 on spreads this season (+24 units!)

NFL Week 11 Kansas City Chiefs vs Los Angeles Chargers prediction

Historically, meetings between the Chiefs and Chargers are close games. Don’t expect much different in this contest, as the Chargers are expecting multiple players back for this pivotal AFC matchup. Kansas City is also coming off a bit of a fortunate cover against the Jaguars, while Los Angeles were just defeated in San Francisco. This should be a fascinating contest, so let’s get into our expert’s predictions.

Kansas City Chiefs vs Los Angeles Chargers spread, odds & betting lines

Point Spread: Chiefs -6, Chargers +6
Total Points Over/Under: 50 points
Money Line Odds: Chiefs -250, Chargers +200

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Be sure to read the rest of our NFL picks for Week 11:

Kansas City Chiefs vs Los Angeles Chargers expert picks

We’ve got 2 standout NFL picks for this week’s clash between the Chiefs and Chargers. 

Kansas City Chiefs vs Los Angeles Chargers point spread pick: Chargers +6 (-110)

This particular matchup hinges on the health of the Chargers 2 best wide receivers. Based on everything I’m ready as of Wednesday both Mike Williams and Keenan Allen will return to practice this week, which means I’m optimistic about them playing on Sunday. My guess is some sharp bettors got ahead of that news earlier this week and took 7 with the Chargers, moving the spread down to the current number of 6.5 at the time of publication. Keep a close eye on the status of both Williams and Allen heading into the weekend. If they both play, I can see this line continuing to trend towards the Chargers; if not, perhaps it has a chance to get back to 7.
The Chiefs are dealing with injury problems of their own. WR JuJu Smith-Schuster and RT Andrew Wylie both suffered concussions in the win over Jacksonville. This is pure speculation, but based on the post-Tua Tagovailoa concussion protocol I would expect both players to miss this Sunday’s game. That means Kansas City could be down to their 3rd-string RT unless Lucas Niang returns from his knee injury. That’s key against a Chargers pass rush that is starting to play better with Khalil Mack, Kenneth Murray and Morgan Fox each generating 2 pressures against Jimmy G and the Niners’ sturdy offensive line last Sunday.
Obviously I’m concerned with the Chargers depth on the interior as they continue to suffer injuries at defensive tackle, but Kansas City is just 26th in rushing success rate this season (38.2%) and their offense is very much pass first. Considering the Chargers held up okay against a much more physical 49ers offense Sunday night, I feel good about this matchup up front. Justin Herbert is 4-1 ATS against the Chiefs in his career and 3-1 ATS against Patrick Mahomes (one of the wins was in the final week of the regular season when KC was resting starters). As long as the Chargers get some punch back on the outside with Williams and Allen returning from injury, I could see this one going down to the wire and would not be shocked if we saw an outright upset.

Be sure to check out our full Kansas City Chiefs vs Los Angeles Chargers predictions

Kansas City Chiefs vs Los Angeles Chargers Over/Under totals pick: Over 50 (-110)

This number will likely tick up a half point or so if Mike Williams and Keenan Allen both return to the lineup. The overarching trends point in the other direction here, including scoring being down across the league and divisional unders hitting at a historic rate through the first 10 weeks (31-16, 66%). I was impressed with the Chiefs’ defense against a good Jaguars front on Sunday, holding the run game in check and allowing just 5.2 yards per play overall.  But the Chargers’ run game has the 4th-lowest success rate in the NFL this season (35.9%) and I just don’t see them leaning on it too much in this matchup unless they are having early success.

Kansas City’s defense has been shaky against the pass in 2022, allowing a 101.9 opponent rating and 19 passing touchdowns. I can absolutely see this game quickly turn into a shootout if Williams/Allen are relatively healthy. Brandon Staley’s defense did a good job keeping Jimmy G and the 49ers’ running game on Sunday night, especially in the red zone — but this Chiefs offense is just a completely different animal and I don’t anticipate Patrick Mahomes settling for 3 field goals inside the 10-yard-line this week. Field goals are always the death of overs, so red-zone efficiency for both teams will be key if this has any chance of sailing past a relatively high total.

Get all of our expert betting insight, analysis and even more NFL Predictions and NFL Best Bets from the rest of the Week 11 action.

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